Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

Meryam El Issaoui; Veronica Giorgione; Linn Salto Mamsen; Catherine Rechnitzer; Niels Birkebæk; Niels Clausen; Thomas W Kelsey; Claus Yding Andersen

doi:10.1016/j.fertnstert.2016.09.001

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

Meryam El Issaoui, Veronica Giorgione, Linn Salto Mamsen, Catherine Rechnitzer, Niels Birkebæk, Niels Clausen, Thomas W Kelsey, Claus Yding Andersen

Institut for Klinisk Medicin

13 Citationer (Scopus)

Abstract

OBJECTIVE: To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse.

DESIGN: Retrospective case-control study.

SETTING: University hospitals.

PATIENT(S): Sixty-three girls under the age of 18 years who underwent OTC before (group 1: 31 patients) and after (group 2: 32 patients) their initial cancer treatment.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Follicular densities (follicles/mm(3)) measured from an ovarian cortical biopsy before OTC. The ovarian volume (mL) of entire ovaries excised for OTC was also monitored.

RESULT(S): There was no statistically significant difference in the mean age or follicular density between groups 1 and 2 (334 ± 476/mm(3) vs. 327 ± 756/mm(3)). In contrast, the ovarian volume and total number of ovarian cortex chips cryopreserved were statistically significantly lower in patients who received gonadotoxic treatment before OTC (mean ± standard deviation [SD]: ovarian volume, 5.3 ± 3.1 mL vs. 2.9 ± 2.1 mL, respectively; number of cortex chips: 21.3 ± 8.1 vs. 15.2 ± 7.1, respectively). The reduction in the estimated ovarian reserve ranged from 10% to 20% in children to around 30% in adolescent girls (>10 years).

CONCLUSION(S): Girls under the age of 10 tolerate a gonadotoxic insult better than adolescents, who may experience up to a 30% reduction in the ovarian reserve via first-line gonadotoxic treatment, which at present is considered to have little effect on the follicle pool. This information will improve counseling of young female cancer patients in deciding whether to undergo fertility preservation treatment.

Originalsprog	Engelsk
Tidsskrift	Fertility and Sterility
Vol/bind	106
Udgave nummer	7
Sider (fra-til)	1757-1762.e1
Antal sider	6
ISSN	0015-0282
DOI	https://doi.org/10.1016/j.fertnstert.2016.09.001
Status	Udgivet - 1 dec. 2016

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10.1016/j.fertnstert.2016.09.001

http://www.fertstert.org/article/S0015028216627917/pdf

Citationsformater

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title = "Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years",

abstract = "OBJECTIVE: To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse.DESIGN: Retrospective case-control study.SETTING: University hospitals.PATIENT(S): Sixty-three girls under the age of 18 years who underwent OTC before (group 1: 31 patients) and after (group 2: 32 patients) their initial cancer treatment.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Follicular densities (follicles/mm(3)) measured from an ovarian cortical biopsy before OTC. The ovarian volume (mL) of entire ovaries excised for OTC was also monitored.RESULT(S): There was no statistically significant difference in the mean age or follicular density between groups 1 and 2 (334 ± 476/mm(3) vs. 327 ± 756/mm(3)). In contrast, the ovarian volume and total number of ovarian cortex chips cryopreserved were statistically significantly lower in patients who received gonadotoxic treatment before OTC (mean ± standard deviation [SD]: ovarian volume, 5.3 ± 3.1 mL vs. 2.9 ± 2.1 mL, respectively; number of cortex chips: 21.3 ± 8.1 vs. 15.2 ± 7.1, respectively). The reduction in the estimated ovarian reserve ranged from 10% to 20% in children to around 30% in adolescent girls (>10 years).CONCLUSION(S): Girls under the age of 10 tolerate a gonadotoxic insult better than adolescents, who may experience up to a 30% reduction in the ovarian reserve via first-line gonadotoxic treatment, which at present is considered to have little effect on the follicle pool. This information will improve counseling of young female cancer patients in deciding whether to undergo fertility preservation treatment.",

keywords = "Journal Article",

author = "{El Issaoui}, Meryam and Veronica Giorgione and Mamsen, {Linn Salto} and Catherine Rechnitzer and Niels Birkeb{\ae}k and Niels Clausen and Kelsey, {Thomas W} and Andersen, {Claus Yding}",

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doi = "10.1016/j.fertnstert.2016.09.001",

language = "English",

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TY - JOUR

T1 - Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

AU - El Issaoui, Meryam

AU - Giorgione, Veronica

AU - Mamsen, Linn Salto

AU - Rechnitzer, Catherine

AU - Birkebæk, Niels

AU - Clausen, Niels

AU - Kelsey, Thomas W

AU - Andersen, Claus Yding

PY - 2016/12/1

Y1 - 2016/12/1

N2 - OBJECTIVE: To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse.DESIGN: Retrospective case-control study.SETTING: University hospitals.PATIENT(S): Sixty-three girls under the age of 18 years who underwent OTC before (group 1: 31 patients) and after (group 2: 32 patients) their initial cancer treatment.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Follicular densities (follicles/mm(3)) measured from an ovarian cortical biopsy before OTC. The ovarian volume (mL) of entire ovaries excised for OTC was also monitored.RESULT(S): There was no statistically significant difference in the mean age or follicular density between groups 1 and 2 (334 ± 476/mm(3) vs. 327 ± 756/mm(3)). In contrast, the ovarian volume and total number of ovarian cortex chips cryopreserved were statistically significantly lower in patients who received gonadotoxic treatment before OTC (mean ± standard deviation [SD]: ovarian volume, 5.3 ± 3.1 mL vs. 2.9 ± 2.1 mL, respectively; number of cortex chips: 21.3 ± 8.1 vs. 15.2 ± 7.1, respectively). The reduction in the estimated ovarian reserve ranged from 10% to 20% in children to around 30% in adolescent girls (>10 years).CONCLUSION(S): Girls under the age of 10 tolerate a gonadotoxic insult better than adolescents, who may experience up to a 30% reduction in the ovarian reserve via first-line gonadotoxic treatment, which at present is considered to have little effect on the follicle pool. This information will improve counseling of young female cancer patients in deciding whether to undergo fertility preservation treatment.

AB - OBJECTIVE: To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse.DESIGN: Retrospective case-control study.SETTING: University hospitals.PATIENT(S): Sixty-three girls under the age of 18 years who underwent OTC before (group 1: 31 patients) and after (group 2: 32 patients) their initial cancer treatment.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Follicular densities (follicles/mm(3)) measured from an ovarian cortical biopsy before OTC. The ovarian volume (mL) of entire ovaries excised for OTC was also monitored.RESULT(S): There was no statistically significant difference in the mean age or follicular density between groups 1 and 2 (334 ± 476/mm(3) vs. 327 ± 756/mm(3)). In contrast, the ovarian volume and total number of ovarian cortex chips cryopreserved were statistically significantly lower in patients who received gonadotoxic treatment before OTC (mean ± standard deviation [SD]: ovarian volume, 5.3 ± 3.1 mL vs. 2.9 ± 2.1 mL, respectively; number of cortex chips: 21.3 ± 8.1 vs. 15.2 ± 7.1, respectively). The reduction in the estimated ovarian reserve ranged from 10% to 20% in children to around 30% in adolescent girls (>10 years).CONCLUSION(S): Girls under the age of 10 tolerate a gonadotoxic insult better than adolescents, who may experience up to a 30% reduction in the ovarian reserve via first-line gonadotoxic treatment, which at present is considered to have little effect on the follicle pool. This information will improve counseling of young female cancer patients in deciding whether to undergo fertility preservation treatment.

KW - Journal Article

U2 - 10.1016/j.fertnstert.2016.09.001

DO - 10.1016/j.fertnstert.2016.09.001

M3 - Journal article

C2 - 27717554

SN - 1546-2501

VL - 106

SP - 1757-1762.e1

JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

IS - 7

ER -

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

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