Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study

Ulrik Winning Iepsen; Gregers Druedal Wibe Munch; Mette Rugbjerg; Anders Rasmussen Rinnov; Morten Zacho; Stefan Peter Mortensen; Niels H. Secher; Thomas Jørgen Ringbæk; Bente Klarlund Pedersen; Ylva Hellsten; Peter Lange; Pia Thaning

doi:10.2147/COPD.S114351

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study

Ulrik Winning Iepsen, Gregers Druedal Wibe Munch, Mette Rugbjerg, Anders Rasmussen Rinnov, Morten Zacho, Stefan Peter Mortensen, Niels H. Secher, Thomas Jørgen Ringbæk, Bente Klarlund Pedersen, Ylva Hellsten, Peter Lange, Pia Thaning

18 Citationer (Scopus)

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Abstract

Introduction: Exercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described. Methods: Thirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT. Vastus lateralis muscle biopsies were obtained before and after the training intervention to assess muscle morphology and metabolic and angiogenic factors. Symptom burden, exercise capacity (6-minute walking and cycle ergometer tests), and vascular function were also assessed. Results: Both training modalities improved symptom burden and exercise capacity with no difference between the two groups. The mean (SD) proportion of glycolytic type IIa muscle fibers was reduced after ET (from 48% [SD 11] to 42% [SD 10], P<0.05), whereas there was no significant change in muscle fiber distribution with RT. There was no effect of either training modality on muscle capillarization, angiogenic factors, or vascular function. After ET the muscle protein content of phosphofructokinase was reduced (P<0.05) and the citrate synthase content tended increase (P=0.08) but no change was observed after RT. Conclusion: Although both ET and RT improve symptoms and exercise capacity, ET induces a more oxidative quadriceps muscle phenotype, counteracting muscle dysfunction in COPD.

Originalsprog	Engelsk
Tidsskrift	The International Journal of Chronic Obstructive Pulmonary Disease (Print)
Vol/bind	11
Sider (fra-til)	2659-2669
Antal sider	11
ISSN	1176-9106
DOI	https://doi.org/10.2147/COPD.S114351
Status	Udgivet - 27 okt. 2016

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10.2147/COPD.S114351Licens: CC BY

Iepsen et al_International Journal of COPD_2016_Vol 11(1)_2659-2669Forlagets udgivne version, 2,03 MBLicens: CC BY

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Iepsen, U. W., Munch, G. D. W., Rugbjerg, M., Rinnov, A. R., Zacho, M., Mortensen, S. P., Secher, N. H., Ringbæk, T. J., Pedersen, B. K., Hellsten, Y., Lange, P., & Thaning, P. (2016). Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study. The International Journal of Chronic Obstructive Pulmonary Disease (Print), 11, 2659-2669. https://doi.org/10.2147/COPD.S114351

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study. / Iepsen, Ulrik Winning; Munch, Gregers Druedal Wibe; Rugbjerg, Mette et al.
I: The International Journal of Chronic Obstructive Pulmonary Disease (Print), Bind 11, 27.10.2016, s. 2659-2669.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Iepsen, UW, Munch, GDW, Rugbjerg, M, Rinnov, AR, Zacho, M, Mortensen, SP, Secher, NH, Ringbæk, TJ, Pedersen, BK , Hellsten, Y , Lange, P & Thaning, P 2016, 'Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study', The International Journal of Chronic Obstructive Pulmonary Disease (Print), bind 11, s. 2659-2669. https://doi.org/10.2147/COPD.S114351

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title = "Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study",

abstract = "Introduction: Exercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described. Methods: Thirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT. Vastus lateralis muscle biopsies were obtained before and after the training intervention to assess muscle morphology and metabolic and angiogenic factors. Symptom burden, exercise capacity (6-minute walking and cycle ergometer tests), and vascular function were also assessed. Results: Both training modalities improved symptom burden and exercise capacity with no difference between the two groups. The mean (SD) proportion of glycolytic type IIa muscle fibers was reduced after ET (from 48% [SD 11] to 42% [SD 10], P<0.05), whereas there was no significant change in muscle fiber distribution with RT. There was no effect of either training modality on muscle capillarization, angiogenic factors, or vascular function. After ET the muscle protein content of phosphofructokinase was reduced (P<0.05) and the citrate synthase content tended increase (P=0.08) but no change was observed after RT. Conclusion: Although both ET and RT improve symptoms and exercise capacity, ET induces a more oxidative quadriceps muscle phenotype, counteracting muscle dysfunction in COPD.",

keywords = "Faculty of Science, Muscle fibers, Phosphofructokinase-1, Vasodilation, Rehabilitation, Randomized controlled trial",

author = "Iepsen, {Ulrik Winning} and Munch, {Gregers Druedal Wibe} and Mette Rugbjerg and Rinnov, {Anders Rasmussen} and Morten Zacho and Mortensen, {Stefan Peter} and Secher, {Niels H.} and Ringb{\ae}k, {Thomas J{\o}rgen} and Pedersen, {Bente Klarlund} and Ylva Hellsten and Peter Lange and Pia Thaning",

note = "CURIS 2016 NEXS 323",

year = "2016",

month = oct,

day = "27",

doi = "10.2147/COPD.S114351",

language = "English",

volume = "11",

pages = "2659--2669",

journal = "The International Journal of Chronic Obstructive Pulmonary Disease (Print)",

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TY - JOUR

T1 - Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD

T2 - a pilot study

AU - Iepsen, Ulrik Winning

AU - Munch, Gregers Druedal Wibe

AU - Rugbjerg, Mette

AU - Rinnov, Anders Rasmussen

AU - Zacho, Morten

AU - Mortensen, Stefan Peter

AU - Secher, Niels H.

AU - Ringbæk, Thomas Jørgen

AU - Pedersen, Bente Klarlund

AU - Hellsten, Ylva

AU - Lange, Peter

AU - Thaning, Pia

N1 - CURIS 2016 NEXS 323

PY - 2016/10/27

Y1 - 2016/10/27

N2 - Introduction: Exercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described. Methods: Thirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT. Vastus lateralis muscle biopsies were obtained before and after the training intervention to assess muscle morphology and metabolic and angiogenic factors. Symptom burden, exercise capacity (6-minute walking and cycle ergometer tests), and vascular function were also assessed. Results: Both training modalities improved symptom burden and exercise capacity with no difference between the two groups. The mean (SD) proportion of glycolytic type IIa muscle fibers was reduced after ET (from 48% [SD 11] to 42% [SD 10], P<0.05), whereas there was no significant change in muscle fiber distribution with RT. There was no effect of either training modality on muscle capillarization, angiogenic factors, or vascular function. After ET the muscle protein content of phosphofructokinase was reduced (P<0.05) and the citrate synthase content tended increase (P=0.08) but no change was observed after RT. Conclusion: Although both ET and RT improve symptoms and exercise capacity, ET induces a more oxidative quadriceps muscle phenotype, counteracting muscle dysfunction in COPD.

AB - Introduction: Exercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described. Methods: Thirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT. Vastus lateralis muscle biopsies were obtained before and after the training intervention to assess muscle morphology and metabolic and angiogenic factors. Symptom burden, exercise capacity (6-minute walking and cycle ergometer tests), and vascular function were also assessed. Results: Both training modalities improved symptom burden and exercise capacity with no difference between the two groups. The mean (SD) proportion of glycolytic type IIa muscle fibers was reduced after ET (from 48% [SD 11] to 42% [SD 10], P<0.05), whereas there was no significant change in muscle fiber distribution with RT. There was no effect of either training modality on muscle capillarization, angiogenic factors, or vascular function. After ET the muscle protein content of phosphofructokinase was reduced (P<0.05) and the citrate synthase content tended increase (P=0.08) but no change was observed after RT. Conclusion: Although both ET and RT improve symptoms and exercise capacity, ET induces a more oxidative quadriceps muscle phenotype, counteracting muscle dysfunction in COPD.

KW - Faculty of Science

KW - Muscle fibers

KW - Phosphofructokinase-1

KW - Vasodilation

KW - Rehabilitation

KW - Randomized controlled trial

U2 - 10.2147/COPD.S114351

DO - 10.2147/COPD.S114351

M3 - Journal article

C2 - 27822028

SN - 1176-9106

VL - 11

SP - 2659

EP - 2669

JO - The International Journal of Chronic Obstructive Pulmonary Disease (Print)

JF - The International Journal of Chronic Obstructive Pulmonary Disease (Print)

ER -

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study

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