Effect of antibiotics on gut microbiota, glucose metabolism and bodyweight regulation: a review of the literature

TY - JOUR

T1 - Effect of antibiotics on gut microbiota, glucose metabolism and bodyweight regulation

T2 - a review of the literature

AU - Mikkelsen, Kristian Hallundbaek

AU - Allin, Kristine Højgaard

AU - Knop, Filip Krag

N1 - This article is protected by copyright. All rights reserved.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Gut bacteria are involved in a number of host metabolic processes and have been implicated in the development of obesity and type 2 diabetes in humans. The use of antibiotics changes the composition of the gut microbiota and there is accumulating evidence from observational studies for an association between exposure to antibiotics and development of obesity and type 2 diabetes. In the present paper, we review human studies examining the effects of antibiotics on body weight regulation and glucose metabolism and discuss whether the observed findings may relate to alterations in the composition and function of the gut microbiota.

AB - Gut bacteria are involved in a number of host metabolic processes and have been implicated in the development of obesity and type 2 diabetes in humans. The use of antibiotics changes the composition of the gut microbiota and there is accumulating evidence from observational studies for an association between exposure to antibiotics and development of obesity and type 2 diabetes. In the present paper, we review human studies examining the effects of antibiotics on body weight regulation and glucose metabolism and discuss whether the observed findings may relate to alterations in the composition and function of the gut microbiota.

U2 - 10.1111/dom.12637

DO - 10.1111/dom.12637

M3 - Review

C2 - 26818734

SN - 1462-8902

VL - 18

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

IS - 5

M1 - 444–453

ER -