Ecdysone control of developmental transitions: lessons from Drosophila research

TY - JOUR

T1 - Ecdysone control of developmental transitions

T2 - lessons from Drosophila research

AU - Yamanaka, Naoki

AU - Rewitz, Kim F

AU - O'Connor, Michael B

PY - 2013/1/7

Y1 - 2013/1/7

N2 - The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent new advances in our understanding of ecdysone action have relied heavily on the application of Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, we focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage- and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signaling.

AB - The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent new advances in our understanding of ecdysone action have relied heavily on the application of Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, we focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage- and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signaling.

U2 - 10.1146/annurev-ento-120811-153608

DO - 10.1146/annurev-ento-120811-153608

M3 - Journal article

C2 - 23072462

SN - 0066-4170

VL - 58

SP - 497

EP - 516

JO - Annual Review of Entomology

JF - Annual Review of Entomology

ER -