Early Postoperative 18F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors

Lisbeth Marner; Karsten Nysom; Astrid Sehested; Lise Borgwardt; René Mathiasen; Otto Mølby Henriksen; Michael Lundemann; Per Munck Af Rosenschöld; Carsten Thomsen; Lars Bøgeskov; Jane Skjøth-Rasmussen; Marianne Juhler; Anders Kruse; Helle Broholm; David Scheie; Torsten Lauritsen; Julie Lyng Forman; Peder Skov Wehner; Liselotte Højgaard; Ian Law

doi:10.2967/jnumed.118.220293

Early Postoperative ¹⁸F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors

Lisbeth Marner, Karsten Nysom, Astrid Sehested, Lise Borgwardt, René Mathiasen, Otto Mølby Henriksen, Michael Lundemann, Per Munck Af Rosenschöld, Carsten Thomsen, Lars Bøgeskov, Jane Skjøth-Rasmussen, Marianne Juhler, Anders Kruse, Helle Broholm, David Scheie, Torsten Lauritsen, Julie Lyng Forman, Peder Skov Wehner, Liselotte Højgaard, Ian Law

5 Citationer (Scopus)

Abstract

Complete resection is the treatment of choice for most pediatric brain tumors, but early postoperative MRI for detection of residual tumor may be misleading because of MRI signal changes caused by the operation. PET imaging with amino acid tracers in adults increases the diagnostic accuracy for brain tumors, but the literature in pediatric neurooncology is limited. A hybrid PET/MRI system is highly beneficial in children, reducing the number of scanning procedures, and this is to our knowledge the first larger study using PET/MRI in pediatric neurooncology. We evaluated if additional postoperative ¹⁸F-fluoro-ethyl-tyrosine (¹⁸F-FET) PET in children and adolescents would improve diagnostic accuracy for the detection of residual tumor as compared with MRI alone and would assist clinical management. Methods: Twenty-two patients (7 male; mean age, 9.5 y; range, 0–19 y) were included prospectively and consecutively in the study and had 27 early postoperative ¹⁸F-FET PET exams performed preferentially in a hybrid PET/MRI system (NCT03402425). Results: Using follow-up (93%) or reoperation (7%) as the reference standard, PET combined with MRI discriminated tumor from treatment effects with a lesion-based sensitivity/ specificity/accuracy (95% confidence intervals) of 0.73 (0.50–1.00)/ 1.00 (0.74–1.00)/0.87 (0.73–1.00) compared with MRI alone: 0.80 (0.57–1.00)/0.75 (0.53–0.94)/0.77 (0.65–0.90); that is, the specificity for PET/MRI was 1.00 as compared with 0.75 for MRI alone (P 5 0.13). In 11 of 27 cases (41%), results from the ¹⁸F-FET PET scans added relevant clinical information, including one scan that directly influenced clinical management because an additional residual tumor site was identified. ¹⁸F-FET uptake in reactive changes was frequent (52%), but correct interpretation was possible in all cases. Conclusion: The high specificity for detecting residual tumor suggests that supplementary ¹⁸F-FET PET is relevant in cases where reoperation for residual tumor is considered.

Originalsprog	Engelsk
Tidsskrift	The Journal of Nuclear Medicine
Vol/bind	60
Udgave nummer	8
Sider (fra-til)	1053-1058
Antal sider	6
ISSN	0161-5505
DOI	https://doi.org/10.2967/jnumed.118.220293
Status	Udgivet - 1 aug. 2019

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10.2967/jnumed.118.220293

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Marner, L., Nysom, K., Sehested, A., Borgwardt, L., Mathiasen, R., Henriksen, O. M., Lundemann, M., Munck Af Rosenschöld, P., Thomsen, C., Bøgeskov, L., Skjøth-Rasmussen, J., Juhler, M., Kruse, A., Broholm, H., Scheie, D., Lauritsen, T., Forman, J. L., Wehner, P. S., Højgaard, L., & Law, I. (2019). Early Postoperative ¹⁸F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors. The Journal of Nuclear Medicine, 60(8), 1053-1058. https://doi.org/10.2967/jnumed.118.220293

Marner, L, Nysom, K, Sehested, A, Borgwardt, L, Mathiasen, R, Henriksen, OM, Lundemann, M, Munck Af Rosenschöld, P, Thomsen, C, Bøgeskov, L, Skjøth-Rasmussen, J, Juhler, M, Kruse, A, Broholm, H, Scheie, D, Lauritsen, T, Forman, JL, Wehner, PS, Højgaard, L & Law, I 2019, 'Early Postoperative ¹⁸F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors', The Journal of Nuclear Medicine, bind 60, nr. 8, s. 1053-1058. https://doi.org/10.2967/jnumed.118.220293

@article{64f6039960c346d0ae81cd06e2938e35,

title = "Early Postoperative 18F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors",

abstract = "Complete resection is the treatment of choice for most pediatric brain tumors, but early postoperative MRI for detection of residual tumor may be misleading because of MRI signal changes caused by the operation. PET imaging with amino acid tracers in adults increases the diagnostic accuracy for brain tumors, but the literature in pediatric neurooncology is limited. A hybrid PET/MRI system is highly beneficial in children, reducing the number of scanning procedures, and this is to our knowledge the first larger study using PET/MRI in pediatric neurooncology. We evaluated if additional postoperative 18F-fluoro-ethyl-tyrosine (18F-FET) PET in children and adolescents would improve diagnostic accuracy for the detection of residual tumor as compared with MRI alone and would assist clinical management. Methods: Twenty-two patients (7 male; mean age, 9.5 y; range, 0–19 y) were included prospectively and consecutively in the study and had 27 early postoperative 18F-FET PET exams performed preferentially in a hybrid PET/MRI system (NCT03402425). Results: Using follow-up (93%) or reoperation (7%) as the reference standard, PET combined with MRI discriminated tumor from treatment effects with a lesion-based sensitivity/ specificity/accuracy (95% confidence intervals) of 0.73 (0.50–1.00)/ 1.00 (0.74–1.00)/0.87 (0.73–1.00) compared with MRI alone: 0.80 (0.57–1.00)/0.75 (0.53–0.94)/0.77 (0.65–0.90); that is, the specificity for PET/MRI was 1.00 as compared with 0.75 for MRI alone (P 5 0.13). In 11 of 27 cases (41%), results from the 18F-FET PET scans added relevant clinical information, including one scan that directly influenced clinical management because an additional residual tumor site was identified. 18F-FET uptake in reactive changes was frequent (52%), but correct interpretation was possible in all cases. Conclusion: The high specificity for detecting residual tumor suggests that supplementary 18F-FET PET is relevant in cases where reoperation for residual tumor is considered.",

author = "Lisbeth Marner and Karsten Nysom and Astrid Sehested and Lise Borgwardt and Ren{\'e} Mathiasen and Henriksen, {Otto M{\o}lby} and Michael Lundemann and {Munck Af Rosensch{\"o}ld}, Per and Carsten Thomsen and Lars B{\o}geskov and Jane Skj{\o}th-Rasmussen and Marianne Juhler and Anders Kruse and Helle Broholm and David Scheie and Torsten Lauritsen and Forman, {Julie Lyng} and Wehner, {Peder Skov} and Liselotte H{\o}jgaard and Ian Law",

note = "Copyright {\textcopyright} 2019 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",

year = "2019",

month = aug,

day = "1",

doi = "10.2967/jnumed.118.220293",

language = "English",

volume = "60",

pages = "1053--1058",

journal = "The Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine",

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TY - JOUR

T1 - Early Postoperative 18F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors

AU - Marner, Lisbeth

AU - Nysom, Karsten

AU - Sehested, Astrid

AU - Borgwardt, Lise

AU - Mathiasen, René

AU - Henriksen, Otto Mølby

AU - Lundemann, Michael

AU - Munck Af Rosenschöld, Per

AU - Thomsen, Carsten

AU - Bøgeskov, Lars

AU - Skjøth-Rasmussen, Jane

AU - Juhler, Marianne

AU - Kruse, Anders

AU - Broholm, Helle

AU - Scheie, David

AU - Lauritsen, Torsten

AU - Forman, Julie Lyng

AU - Wehner, Peder Skov

AU - Højgaard, Liselotte

AU - Law, Ian

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Complete resection is the treatment of choice for most pediatric brain tumors, but early postoperative MRI for detection of residual tumor may be misleading because of MRI signal changes caused by the operation. PET imaging with amino acid tracers in adults increases the diagnostic accuracy for brain tumors, but the literature in pediatric neurooncology is limited. A hybrid PET/MRI system is highly beneficial in children, reducing the number of scanning procedures, and this is to our knowledge the first larger study using PET/MRI in pediatric neurooncology. We evaluated if additional postoperative 18F-fluoro-ethyl-tyrosine (18F-FET) PET in children and adolescents would improve diagnostic accuracy for the detection of residual tumor as compared with MRI alone and would assist clinical management. Methods: Twenty-two patients (7 male; mean age, 9.5 y; range, 0–19 y) were included prospectively and consecutively in the study and had 27 early postoperative 18F-FET PET exams performed preferentially in a hybrid PET/MRI system (NCT03402425). Results: Using follow-up (93%) or reoperation (7%) as the reference standard, PET combined with MRI discriminated tumor from treatment effects with a lesion-based sensitivity/ specificity/accuracy (95% confidence intervals) of 0.73 (0.50–1.00)/ 1.00 (0.74–1.00)/0.87 (0.73–1.00) compared with MRI alone: 0.80 (0.57–1.00)/0.75 (0.53–0.94)/0.77 (0.65–0.90); that is, the specificity for PET/MRI was 1.00 as compared with 0.75 for MRI alone (P 5 0.13). In 11 of 27 cases (41%), results from the 18F-FET PET scans added relevant clinical information, including one scan that directly influenced clinical management because an additional residual tumor site was identified. 18F-FET uptake in reactive changes was frequent (52%), but correct interpretation was possible in all cases. Conclusion: The high specificity for detecting residual tumor suggests that supplementary 18F-FET PET is relevant in cases where reoperation for residual tumor is considered.

AB - Complete resection is the treatment of choice for most pediatric brain tumors, but early postoperative MRI for detection of residual tumor may be misleading because of MRI signal changes caused by the operation. PET imaging with amino acid tracers in adults increases the diagnostic accuracy for brain tumors, but the literature in pediatric neurooncology is limited. A hybrid PET/MRI system is highly beneficial in children, reducing the number of scanning procedures, and this is to our knowledge the first larger study using PET/MRI in pediatric neurooncology. We evaluated if additional postoperative 18F-fluoro-ethyl-tyrosine (18F-FET) PET in children and adolescents would improve diagnostic accuracy for the detection of residual tumor as compared with MRI alone and would assist clinical management. Methods: Twenty-two patients (7 male; mean age, 9.5 y; range, 0–19 y) were included prospectively and consecutively in the study and had 27 early postoperative 18F-FET PET exams performed preferentially in a hybrid PET/MRI system (NCT03402425). Results: Using follow-up (93%) or reoperation (7%) as the reference standard, PET combined with MRI discriminated tumor from treatment effects with a lesion-based sensitivity/ specificity/accuracy (95% confidence intervals) of 0.73 (0.50–1.00)/ 1.00 (0.74–1.00)/0.87 (0.73–1.00) compared with MRI alone: 0.80 (0.57–1.00)/0.75 (0.53–0.94)/0.77 (0.65–0.90); that is, the specificity for PET/MRI was 1.00 as compared with 0.75 for MRI alone (P 5 0.13). In 11 of 27 cases (41%), results from the 18F-FET PET scans added relevant clinical information, including one scan that directly influenced clinical management because an additional residual tumor site was identified. 18F-FET uptake in reactive changes was frequent (52%), but correct interpretation was possible in all cases. Conclusion: The high specificity for detecting residual tumor suggests that supplementary 18F-FET PET is relevant in cases where reoperation for residual tumor is considered.

U2 - 10.2967/jnumed.118.220293

DO - 10.2967/jnumed.118.220293

M3 - Journal article

C2 - 30683767

SN - 0161-5505

VL - 60

SP - 1053

EP - 1058

JO - The Journal of Nuclear Medicine

JF - The Journal of Nuclear Medicine

IS - 8

ER -

Early Postoperative 18F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors

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Early Postoperative ¹⁸F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors