Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass

Kirstine N Bojsen-Møller; Carsten Dirksen; Nils Bruun Jørgensen; Siv Hesse Jacobsen; Annette Karen Lundbeck Serup; Peter Hjorth Albers; Dorte L Hansen; Dorte Worm; Lars Naver; Viggo B Kristiansen; Jørgen Wojtaszewski; Bente Kiens; Jens J Holst; Erik Richter; Sten Madsbad

doi:10.2337/db13-1307

Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass

Kirstine N Bojsen-Møller, Carsten Dirksen, Nils Bruun Jørgensen, Siv Hesse Jacobsen, Annette Karen Lundbeck Serup, Peter Hjorth Albers, Dorte L Hansen, Dorte Worm, Lars Naver, Viggo B Kristiansen, Jørgen Wojtaszewski, Bente Kiens, Jens J Holst, Erik Richter, Sten Madsbad

159 Citationer (Scopus)

Abstract

Roux-en-Y gastric bypass (RYGB) improves glycemic control within days after surgery, and changes in insulin sensitivity and β-cell function are likely to be involved. We studied 10 obese patients with type 2 diabetes (T2D) and 10 obese glucose-tolerant subjects before and 1 week, 3 months, and 1 year after RYGB. Participants were included after a preoperative diet-induced total weight loss of -9.2 ± 1.2%. Hepatic and peripheral insulin sensitivity were assessed using the hyperinsulinemic-euglycemic clamp combined with the glucose tracer technique, and β-cell function was evaluated in response to an intravenous glucose-glucagon challenge as well as an oral glucose load. Within 1 week, RYGB reduced basal glucose production, improved basal hepatic insulin sensitivity, and increased insulin clearance, highlighting the liver as an important organ responsible for early effects on glucose metabolism after surgery. Insulin-mediated glucose disposal and suppression of fatty acids did not improve immediately after surgery but increased at 3 months and 1 year; this increase likely was related to the reduction in body weight. Insulin secretion increased after RYGB only in patients with T2D and only in response to oral glucose, underscoring the importance of the changed gut anatomy.

Originalsprog	Engelsk
Tidsskrift	Diabetes
Vol/bind	63
Udgave nummer	5
Sider (fra-til)	1725-1737
Antal sider	13
ISSN	0012-1797
DOI	https://doi.org/10.2337/db13-1307
Status	Udgivet - maj 2014

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Bojsen-Møller, K. N., Dirksen, C., Jørgensen, N. B., Jacobsen, S. H., Serup, A. K. L., Albers, P. H., Hansen, D. L., Worm, D., Naver, L., Kristiansen, V. B., Wojtaszewski, J., Kiens, B., Holst, J. J., Richter, E., & Madsbad, S. (2014). Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass. Diabetes, 63(5), 1725-1737. https://doi.org/10.2337/db13-1307

Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass. / Bojsen-Møller, Kirstine N; Dirksen, Carsten; Jørgensen, Nils Bruun et al.

I: Diabetes, Bind 63, Nr. 5, 05.2014, s. 1725-1737.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Bojsen-Møller, KN, Dirksen, C, Jørgensen, NB, Jacobsen, SH, Serup, AKL, Albers, PH, Hansen, DL, Worm, D, Naver, L, Kristiansen, VB, Wojtaszewski, J , Kiens, B , Holst, JJ , Richter, E & Madsbad, S 2014, 'Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass', Diabetes, bind 63, nr. 5, s. 1725-1737. https://doi.org/10.2337/db13-1307

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title = "Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass",

abstract = "Roux-en-Y gastric bypass (RYGB) improves glycemic control within days after surgery, and changes in insulin sensitivity and β-cell function are likely to be involved. We studied 10 obese patients with type 2 diabetes (T2D) and 10 obese glucose-tolerant subjects before and 1 week, 3 months, and 1 year after RYGB. Participants were included after a preoperative diet-induced total weight loss of -9.2 ± 1.2%. Hepatic and peripheral insulin sensitivity were assessed using the hyperinsulinemic-euglycemic clamp combined with the glucose tracer technique, and β-cell function was evaluated in response to an intravenous glucose-glucagon challenge as well as an oral glucose load. Within 1 week, RYGB reduced basal glucose production, improved basal hepatic insulin sensitivity, and increased insulin clearance, highlighting the liver as an important organ responsible for early effects on glucose metabolism after surgery. Insulin-mediated glucose disposal and suppression of fatty acids did not improve immediately after surgery but increased at 3 months and 1 year; this increase likely was related to the reduction in body weight. Insulin secretion increased after RYGB only in patients with T2D and only in response to oral glucose, underscoring the importance of the changed gut anatomy.",

author = "Bojsen-M{\o}ller, {Kirstine N} and Carsten Dirksen and J{\o}rgensen, {Nils Bruun} and Jacobsen, {Siv Hesse} and Serup, {Annette Karen Lundbeck} and Albers, {Peter Hjorth} and Hansen, {Dorte L} and Dorte Worm and Lars Naver and Kristiansen, {Viggo B} and J{\o}rgen Wojtaszewski and Bente Kiens and Holst, {Jens J} and Erik Richter and Sten Madsbad",

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T1 - Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass

AU - Bojsen-Møller, Kirstine N

AU - Dirksen, Carsten

AU - Jørgensen, Nils Bruun

AU - Jacobsen, Siv Hesse

AU - Serup, Annette Karen Lundbeck

AU - Albers, Peter Hjorth

AU - Hansen, Dorte L

AU - Worm, Dorte

AU - Naver, Lars

AU - Kristiansen, Viggo B

AU - Wojtaszewski, Jørgen

AU - Kiens, Bente

AU - Holst, Jens J

AU - Richter, Erik

AU - Madsbad, Sten

N1 - CURIS 2014 NEXS 121

PY - 2014/5

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N2 - Roux-en-Y gastric bypass (RYGB) improves glycemic control within days after surgery, and changes in insulin sensitivity and β-cell function are likely to be involved. We studied 10 obese patients with type 2 diabetes (T2D) and 10 obese glucose-tolerant subjects before and 1 week, 3 months, and 1 year after RYGB. Participants were included after a preoperative diet-induced total weight loss of -9.2 ± 1.2%. Hepatic and peripheral insulin sensitivity were assessed using the hyperinsulinemic-euglycemic clamp combined with the glucose tracer technique, and β-cell function was evaluated in response to an intravenous glucose-glucagon challenge as well as an oral glucose load. Within 1 week, RYGB reduced basal glucose production, improved basal hepatic insulin sensitivity, and increased insulin clearance, highlighting the liver as an important organ responsible for early effects on glucose metabolism after surgery. Insulin-mediated glucose disposal and suppression of fatty acids did not improve immediately after surgery but increased at 3 months and 1 year; this increase likely was related to the reduction in body weight. Insulin secretion increased after RYGB only in patients with T2D and only in response to oral glucose, underscoring the importance of the changed gut anatomy.

AB - Roux-en-Y gastric bypass (RYGB) improves glycemic control within days after surgery, and changes in insulin sensitivity and β-cell function are likely to be involved. We studied 10 obese patients with type 2 diabetes (T2D) and 10 obese glucose-tolerant subjects before and 1 week, 3 months, and 1 year after RYGB. Participants were included after a preoperative diet-induced total weight loss of -9.2 ± 1.2%. Hepatic and peripheral insulin sensitivity were assessed using the hyperinsulinemic-euglycemic clamp combined with the glucose tracer technique, and β-cell function was evaluated in response to an intravenous glucose-glucagon challenge as well as an oral glucose load. Within 1 week, RYGB reduced basal glucose production, improved basal hepatic insulin sensitivity, and increased insulin clearance, highlighting the liver as an important organ responsible for early effects on glucose metabolism after surgery. Insulin-mediated glucose disposal and suppression of fatty acids did not improve immediately after surgery but increased at 3 months and 1 year; this increase likely was related to the reduction in body weight. Insulin secretion increased after RYGB only in patients with T2D and only in response to oral glucose, underscoring the importance of the changed gut anatomy.

U2 - 10.2337/db13-1307

DO - 10.2337/db13-1307

M3 - Journal article

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SN - 0012-1797

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SP - 1725

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JO - Diabetes

JF - Diabetes

IS - 5

ER -

Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass

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