Dynamic combinatorial chemistry

Brian Rasmussen; Anne Sørensen; Sophie R. Beeren; Michael Pittelkow

doi:10.1002/9781118736449.ch14

Dynamic combinatorial chemistry

Brian Rasmussen, Anne Sørensen, Sophie R. Beeren, Michael Pittelkow

Kemisk Institut

3 Citationer (Scopus)

Abstract

This chapter explains how dynamic combinatorial chemistry is used to study molecular recognition. It illustrates how the use of a small number of dithiol building blocks can create large diversity in disulfide-dynamic combinatorial libraries (DCLs). The chapter shows how DCLs can be used to optimize the binding properties of already known receptors for anions and how the exploration of DCLs has led to new knowledge about mechanically interlocked molecules. It describes pseudopeptide DCLs, and discusses the application of boronate transesterification in dynamic combinatorial chemistry. It also describes how DCLs can target biologically interesting molecules. A section explains how modeling studies using computational methods have been used to aid in library design and how the determination of binding constants between DCL members and templates can be achieved by means of modeling studies without actually isolating the receptors.

Originalsprog	Engelsk
Titel	Organic synthesis and molecular engineering
Redaktører	Mogens Brøndsted Nielsen
Antal sider	44
Forlag	Wiley
Publikationsdato	25 okt. 2013
Sider	393-436
Kapitel	14
ISBN (Trykt)	9781118150924
ISBN (Elektronisk)	9781118736449
DOI	https://doi.org/10.1002/9781118736449.ch14
Status	Udgivet - 25 okt. 2013

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10.1002/9781118736449.ch14

Citationsformater

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Dynamic combinatorial chemistry

Abstract

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