TY - JOUR
T1 - Dynamic changes in the transcriptional profile of subventricular zone-derived postnatally born neuroblasts
AU - Khodosevich, Konstantin
AU - Alfonso, Julieta
AU - Monyer, Hannah
N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PY - 2013
Y1 - 2013
N2 - The subventricular zone (SVZ) of the lateral ventricles is a major neurogenic region in the postnatal mammalian brain. Thousands of neuroblasts are generated daily throughout the life of an animal. Newly born neuroblasts migrate via the rostral migratory stream (RMS) into the olfactory bulb where they mature into distinct neuronal subtypes. Neuroblasts exiting the SVZ retain the ability to proliferate, however, proliferation declines in the course of migration to the olfactory bulb. While migrating in the RMS, neuroblasts receive a plethora of stimuli that modify transcription according to the local microenvironment, and eventually modulate neuroblast migration. In the target area, the olfactory bulb, neuroblasts develop into mature neurons. In this review, we discuss dynamic changes of the transcriptome that occur during the "lifetime" of a neuroblast, thereby governing the activation or inhibition of distinct genes/pathways that are responsible for proliferation, migration and differentiation.
AB - The subventricular zone (SVZ) of the lateral ventricles is a major neurogenic region in the postnatal mammalian brain. Thousands of neuroblasts are generated daily throughout the life of an animal. Newly born neuroblasts migrate via the rostral migratory stream (RMS) into the olfactory bulb where they mature into distinct neuronal subtypes. Neuroblasts exiting the SVZ retain the ability to proliferate, however, proliferation declines in the course of migration to the olfactory bulb. While migrating in the RMS, neuroblasts receive a plethora of stimuli that modify transcription according to the local microenvironment, and eventually modulate neuroblast migration. In the target area, the olfactory bulb, neuroblasts develop into mature neurons. In this review, we discuss dynamic changes of the transcriptome that occur during the "lifetime" of a neuroblast, thereby governing the activation or inhibition of distinct genes/pathways that are responsible for proliferation, migration and differentiation.
KW - Animals
KW - Cell Differentiation
KW - Cell Movement
KW - Gene Expression Regulation, Developmental
KW - Lateral Ventricles/cytology
KW - Mice
KW - Nerve Tissue Proteins/genetics
KW - Neural Stem Cells/cytology
KW - Neurogenesis/genetics
KW - Neurons/cytology
KW - Olfactory Bulb/cytology
KW - Signal Transduction
KW - Transcription, Genetic
U2 - 10.1016/j.mod.2012.11.003
DO - 10.1016/j.mod.2012.11.003
M3 - Review
C2 - 23220001
SN - 0925-4773
VL - 130
SP - 424
EP - 432
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 6-8
ER -