Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic Arthritis

Alexander Egeberg; Lone Skov; Claus Zachariae; Gunnar H Gislason; Jacob P Thyssen; Lotus Mallbris

doi:10.2340/00015555-2912

Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic Arthritis

Alexander Egeberg, Lone Skov, Claus Zachariae, Gunnar H Gislason, Jacob P Thyssen, Lotus Mallbris

Institut for Klinisk Medicin

3 Citationer (Scopus)

41 Downloads (Pure)

Abstract

It is unclear whether psoriasis is a progressive disease that requires early aggressive intervention. This population-based study identified patients with psoriasis and psoriatic arthritis (PsA). Survival analysis and Kaplan-Meier life table techniques were used. The study comprised 10,011 psoriasis patients (severe n = 4,618), and 1,269 patients also had PsA. Incidence of PsA increased with duration of cutaneous symptoms (p = 0.0001). Psoriasis diagnosed before age 20 or 30 years, respectively, suggested a lower risk of PsA than psoriasis diagnosed after age 50 years, yet age at first cutaneous symptoms did not predict development of PsA. No clear association with disease severity was found. PsA incidence appeared stable with longer duration of psoriasis, but further data are needed to firmly establish the relationship with age of psoriasis onset.

Originalsprog	Engelsk
Tidsskrift	Acta Dermato-Venereologica
Vol/bind	98
Udgave nummer	6
Sider (fra-til)	546-550
ISSN	0001-5555
DOI	https://doi.org/10.2340/00015555-2912
Status	Udgivet - jun. 2018

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10.2340/00015555-2912Licens: CC BY-NC

Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic ArthritisForlagets udgivne version, 398 KBLicens: CC BY-NC

Citationsformater

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title = "Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic Arthritis",

abstract = "It is unclear whether psoriasis is a progressive disease that requires early aggressive intervention. This population-based study identified patients with psoriasis and psoriatic arthritis (PsA). Survival analysis and Kaplan-Meier life table techniques were used. The study comprised 10,011 psoriasis patients (severe n = 4,618), and 1,269 patients also had PsA. Incidence of PsA increased with duration of cutaneous symptoms (p = 0.0001). Psoriasis diagnosed before age 20 or 30 years, respectively, suggested a lower risk of PsA than psoriasis diagnosed after age 50 years, yet age at first cutaneous symptoms did not predict development of PsA. No clear association with disease severity was found. PsA incidence appeared stable with longer duration of psoriasis, but further data are needed to firmly establish the relationship with age of psoriasis onset.",

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author = "Alexander Egeberg and Lone Skov and Claus Zachariae and Gislason, {Gunnar H} and Thyssen, {Jacob P} and Lotus Mallbris",

year = "2018",

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T1 - Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic Arthritis

AU - Egeberg, Alexander

AU - Skov, Lone

AU - Zachariae, Claus

AU - Gislason, Gunnar H

AU - Thyssen, Jacob P

AU - Mallbris, Lotus

PY - 2018/6

Y1 - 2018/6

N2 - It is unclear whether psoriasis is a progressive disease that requires early aggressive intervention. This population-based study identified patients with psoriasis and psoriatic arthritis (PsA). Survival analysis and Kaplan-Meier life table techniques were used. The study comprised 10,011 psoriasis patients (severe n = 4,618), and 1,269 patients also had PsA. Incidence of PsA increased with duration of cutaneous symptoms (p = 0.0001). Psoriasis diagnosed before age 20 or 30 years, respectively, suggested a lower risk of PsA than psoriasis diagnosed after age 50 years, yet age at first cutaneous symptoms did not predict development of PsA. No clear association with disease severity was found. PsA incidence appeared stable with longer duration of psoriasis, but further data are needed to firmly establish the relationship with age of psoriasis onset.

AB - It is unclear whether psoriasis is a progressive disease that requires early aggressive intervention. This population-based study identified patients with psoriasis and psoriatic arthritis (PsA). Survival analysis and Kaplan-Meier life table techniques were used. The study comprised 10,011 psoriasis patients (severe n = 4,618), and 1,269 patients also had PsA. Incidence of PsA increased with duration of cutaneous symptoms (p = 0.0001). Psoriasis diagnosed before age 20 or 30 years, respectively, suggested a lower risk of PsA than psoriasis diagnosed after age 50 years, yet age at first cutaneous symptoms did not predict development of PsA. No clear association with disease severity was found. PsA incidence appeared stable with longer duration of psoriasis, but further data are needed to firmly establish the relationship with age of psoriasis onset.

KW - Adult

KW - Age of Onset

KW - Aged

KW - Arthritis, Psoriatic/diagnosis

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Kaplan-Meier Estimate

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Prevalence

KW - Psoriasis/diagnosis

KW - Registries

KW - Risk Factors

KW - Time Factors

KW - Young Adult

U2 - 10.2340/00015555-2912

DO - 10.2340/00015555-2912

M3 - Journal article

C2 - 29487945

SN - 0001-5555

VL - 98

SP - 546

EP - 550

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

IS - 6

ER -

Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic Arthritis

Abstract

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