@article{610638a0a60111df928f000ea68e967b,
title = "DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study",
abstract = "BACKGROUND: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. METHODS: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. RESULTS: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. CONCLUSIONS: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.",
author = "J{\"o}nsson, {Erik G} and Peter Saetre and Maria Vares and Dimitrios Andreou and Kristina Larsson and Sally Timm and Rasmussen, {Henrik B} and Srdjan Djurovic and Ingrid Melle and Andreassen, {Ole A} and Ingrid Agartz and Thomas Werge and H{\aa}kan Hall and Lars Terenius and J{\"o}nsson, {Erik G} and Peter Saetre and Maria Vares and Dimitrios Andreou and Kristina Larsson and Sally Timm and Rasmussen, {Henrik B} and Srdjan Djurovic and Ingrid Melle and Andreassen, {Ole A} and Ingrid Agartz and Thomas Werge and H{\aa}kan Hall and Lars Terenius",
note = "Keywords: Adult; Alleles; Carrier Proteins; Case-Control Studies; D-Amino-Acid Oxidase; DNA Mutational Analysis; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Nerve Tissue Proteins; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, Metabotropic Glutamate; Schizophrenia",
year = "2009",
doi = "10.1159/000218076",
language = "English",
volume = "59",
pages = "142--50",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S Karger AG",
number = "3",
}