Double-blind trial of bestatin in HIV-positive patients

M Hørding; P C Gøtzsche; L Dalh Christensen; Ib Christian Bygbjerg; V Faber

Double-blind trial of bestatin in HIV-positive patients

M Hørding, P C Gøtzsche, L Dalh Christensen, Ib Christian Bygbjerg, V Faber

LUKKET: Institut for Immunologi og Mikrobiologi

4 Citationer (Scopus)

Abstract

Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytohaemagglutinin, and concanavalin A, surface marker analysis of T-helper/T-suppressor cells by flow cytometry, natural killer cell activity, beta-2-microglobulin and HIV antibody quantitation. No significant differences between bestatin and placebo in immunological, haematological, biochemical or clinical variables were detected.

Originalsprog	Engelsk
Tidsskrift	Biomedicine & Pharmacotherapy
Vol/bind	44
Udgave nummer	9
Sider (fra-til)	475-8
Antal sider	4
ISSN	0753-3322
Status	Udgivet - 1 jan. 1990

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Citationsformater

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title = "Double-blind trial of bestatin in HIV-positive patients",

abstract = "Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytohaemagglutinin, and concanavalin A, surface marker analysis of T-helper/T-suppressor cells by flow cytometry, natural killer cell activity, beta-2-microglobulin and HIV antibody quantitation. No significant differences between bestatin and placebo in immunological, haematological, biochemical or clinical variables were detected.",

keywords = "Adjuvants, Immunologic, Aminopeptidases, Double-Blind Method, HIV Infections, HIV Seropositivity, Humans, Leucine, Male",

author = "M H{\o}rding and G{\o}tzsche, {P C} and {Dalh Christensen}, L and Bygbjerg, {Ib Christian} and V Faber",

year = "1990",

month = jan,

day = "1",

language = "English",

volume = "44",

pages = "475--8",

journal = "Biomedicine and Pharmacotherapy",

issn = "0753-3322",

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TY - JOUR

T1 - Double-blind trial of bestatin in HIV-positive patients

AU - Hørding, M

AU - Gøtzsche, P C

AU - Dalh Christensen, L

AU - Bygbjerg, Ib Christian

AU - Faber, V

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytohaemagglutinin, and concanavalin A, surface marker analysis of T-helper/T-suppressor cells by flow cytometry, natural killer cell activity, beta-2-microglobulin and HIV antibody quantitation. No significant differences between bestatin and placebo in immunological, haematological, biochemical or clinical variables were detected.

AB - Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytohaemagglutinin, and concanavalin A, surface marker analysis of T-helper/T-suppressor cells by flow cytometry, natural killer cell activity, beta-2-microglobulin and HIV antibody quantitation. No significant differences between bestatin and placebo in immunological, haematological, biochemical or clinical variables were detected.

KW - Adjuvants, Immunologic

KW - Aminopeptidases

KW - Double-Blind Method

KW - HIV Infections

KW - HIV Seropositivity

KW - Humans

KW - Leucine

KW - Male

M3 - Journal article

C2 - 2081275

SN - 0753-3322

VL - 44

SP - 475

EP - 478

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

IS - 9

ER -

Double-blind trial of bestatin in HIV-positive patients

Abstract

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