Dofetilid til patienter med hjerteinsufficiens og dårligt fungerende venstre ventrikel

TY - JOUR

T1 - Dofetilid til patienter med hjerteinsufficiens og dårligt fungerende venstre ventrikel

AU - Torp-Pedersen, C T

AU - Møller, M

AU - Bloch-Thomsen, P E

AU - Køber, L

AU - Sandøe, E

AU - Egstrup, K

AU - Agner, E

AU - Carlsen, J E

AU - Videbaek, J

N1 - Keywords: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cause of Death; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Phenethylamines; Sulfonamides; Ventricular Dysfunction, Left

PY - 2000

Y1 - 2000

N2 - INTRODUCTION: Dofetilide, a new class III antiarrhythmic drug, was tested for its ability to reduce mortality and morbidity in patients with congestive heart failure and left ventricular dysfunction. METHODS: In 34 Danish centers, 1518 patients with NYHA class III or IV heart failure and wall motion index of the left ventricle < or = 1.2 (ejection fraction < or = 35%) were randomized to receive dofetilide or placebo in a double blind study. The dose of dofetilide was adjusted to renal function and the QT interval. Patients were monitored continuously with ekg during the first three days in the study. Minimum follow up was one year. RESULTS: Dofetilide did not affect mortality. Hospitalizations for worsening of heart failure were reduced significantly, hazard ratio 0.75 (0.63-0.89) Dofetilide effectively converted atrial fibrillation to sinus rhythm. After one year, 61% of patients with atrial fibrillation had converted on dofetilide and 33% on placebo (p < 0.001). DISCUSSION: Dofetilide can be used to convert atrial fibrillation to sinus rhythm and to maintain sinus rhythm in patients with congestive heart failure and left ventricular dysfunction. Dofetilide does not affect mortality. Udgivelsesdato: 2000-Oct-30

AB - INTRODUCTION: Dofetilide, a new class III antiarrhythmic drug, was tested for its ability to reduce mortality and morbidity in patients with congestive heart failure and left ventricular dysfunction. METHODS: In 34 Danish centers, 1518 patients with NYHA class III or IV heart failure and wall motion index of the left ventricle < or = 1.2 (ejection fraction < or = 35%) were randomized to receive dofetilide or placebo in a double blind study. The dose of dofetilide was adjusted to renal function and the QT interval. Patients were monitored continuously with ekg during the first three days in the study. Minimum follow up was one year. RESULTS: Dofetilide did not affect mortality. Hospitalizations for worsening of heart failure were reduced significantly, hazard ratio 0.75 (0.63-0.89) Dofetilide effectively converted atrial fibrillation to sinus rhythm. After one year, 61% of patients with atrial fibrillation had converted on dofetilide and 33% on placebo (p < 0.001). DISCUSSION: Dofetilide can be used to convert atrial fibrillation to sinus rhythm and to maintain sinus rhythm in patients with congestive heart failure and left ventricular dysfunction. Dofetilide does not affect mortality. Udgivelsesdato: 2000-Oct-30

M3 - Tidsskriftartikel

C2 - 11094565

SN - 0041-5782

VL - 162

SP - 5948

EP - 5953

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 44

ER -