TY - JOUR
T1 - Disulfides with Anti-inflammatory Activity from the Brown Alga Dictyopteris membranacea
AU - Dimou, Maria
AU - Ioannou, Efstathia
AU - Daskalaki, Maria G
AU - Tziveleka, Leto A
AU - Kampranis, Sotirios
AU - Roussis, Vassilios
PY - 2016/3/25
Y1 - 2016/3/25
N2 - Six new (1, 2, and 4-7) and two previously reported (3 and 8) disulfides, along with 4-butyl-2,6-cycloheptadienone, γ-tocopherol, and δ-tocopherol, were isolated from an organic extract of the brown alga Dictyopteris membranacea, collected at Gerolimenas Bay, Greece. The structure elucidation of the isolated natural products was based on analysis of their spectroscopic data. Compounds 1, 3-6, and 8 were evaluated for their antibacterial and anti-inflammatory activities. None of the compounds displayed antibacterial activity against two resistant strains of Staphylococcus aureus and one strain of Escherichia coli. In contrast, metabolite 5 was able to cause strong inhibition of NO production with an IC50 value of 3.8 μM using an LPS stimulation assay.
AB - Six new (1, 2, and 4-7) and two previously reported (3 and 8) disulfides, along with 4-butyl-2,6-cycloheptadienone, γ-tocopherol, and δ-tocopherol, were isolated from an organic extract of the brown alga Dictyopteris membranacea, collected at Gerolimenas Bay, Greece. The structure elucidation of the isolated natural products was based on analysis of their spectroscopic data. Compounds 1, 3-6, and 8 were evaluated for their antibacterial and anti-inflammatory activities. None of the compounds displayed antibacterial activity against two resistant strains of Staphylococcus aureus and one strain of Escherichia coli. In contrast, metabolite 5 was able to cause strong inhibition of NO production with an IC50 value of 3.8 μM using an LPS stimulation assay.
U2 - 10.1021/acs.jnatprod.5b01031
DO - 10.1021/acs.jnatprod.5b01031
M3 - Journal article
C2 - 26943727
SN - 0163-3864
VL - 79
SP - 584
EP - 589
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 3
ER -