Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety

Avery D Posey; Henrik Clausen; Carl H June

doi:10.1016/j.immuni.2016.10.015

Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety

Avery D Posey, Henrik Clausen, Carl H June

Glycomics Program

19 Citationer (Scopus)

Abstract

Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate potent clinical antitumor effects in a variety of blood cancers. However, clinical activity in solid tumors has been disappointing and toxicity has been a serious concern (Lamers et al., 2013; Morgan et al., 2010). We recently found that a CAR composed of a scFv antibody fragment specific for the Tn-glycoform of MUC1 had potent activity in preclinical models of blood cancer and adenocarcinoma (Posey et al., 2016).

Originalsprog	Engelsk
Tidsskrift	Immunity
Vol/bind	45
Udgave nummer	5
Sider (fra-til)	947-948
Antal sider	2
ISSN	1074-7613
DOI	https://doi.org/10.1016/j.immuni.2016.10.015
Status	Udgivet - 15 nov. 2016

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10.1016/j.immuni.2016.10.015

http://www.cell.com/article/S1074761316304265/pdf

Citationsformater

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title = "Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety",

abstract = "Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate potent clinical antitumor effects in a variety of blood cancers. However, clinical activity in solid tumors has been disappointing and toxicity has been a serious concern (Lamers et al., 2013; Morgan et al., 2010). We recently found that a CAR composed of a scFv antibody fragment specific for the Tn-glycoform of MUC1 had potent activity in preclinical models of blood cancer and adenocarcinoma (Posey et al., 2016).",

author = "Posey, {Avery D} and Henrik Clausen and June, {Carl H}",

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T1 - Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells

T2 - Specificity Is the Key to Safety

AU - Posey, Avery D

AU - Clausen, Henrik

AU - June, Carl H

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate potent clinical antitumor effects in a variety of blood cancers. However, clinical activity in solid tumors has been disappointing and toxicity has been a serious concern (Lamers et al., 2013; Morgan et al., 2010). We recently found that a CAR composed of a scFv antibody fragment specific for the Tn-glycoform of MUC1 had potent activity in preclinical models of blood cancer and adenocarcinoma (Posey et al., 2016).

AB - Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate potent clinical antitumor effects in a variety of blood cancers. However, clinical activity in solid tumors has been disappointing and toxicity has been a serious concern (Lamers et al., 2013; Morgan et al., 2010). We recently found that a CAR composed of a scFv antibody fragment specific for the Tn-glycoform of MUC1 had potent activity in preclinical models of blood cancer and adenocarcinoma (Posey et al., 2016).

U2 - 10.1016/j.immuni.2016.10.015

DO - 10.1016/j.immuni.2016.10.015

M3 - Letter

C2 - 27851918

SN - 1074-7613

VL - 45

SP - 947

EP - 948

JO - Immunity

JF - Immunity

IS - 5

ER -

Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety

Abstract

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