TY - JOUR
T1 - Disease outcome of inflammatory bowel disease patients
T2 - general outline of a Europe-wide population-based 10-year clinical follow-up study
AU - Wolters, Frank L
AU - Russel, Maurice G
AU - Sijbrandij, Jildou
AU - Schouten, Leo J
AU - Odes, Selwyn
AU - Riis, Lene
AU - Munkholm, Pia
AU - Langholz, Ebbe
AU - Bodini, Paolo
AU - O'Morain, Colm
AU - Katsanos, Kostas
AU - Tsianos, Epameinondas
AU - Vermeire, Severine
AU - Van Zeijl, Gilbert
AU - Limonard, Charles
AU - Hoie, Ole
AU - Vatn, Morten
AU - Moum, Bjørn
AU - Stockbrügger, Reinhold W
AU - European Collaborative Study Group on Inflammatory Bowel Disease
PY - 2006
Y1 - 2006
N2 - OBJECTIVE: To give a general outline of a 10-year clinical follow-up study of a population-based European cohort of inflammatory bowel disease (IBD) patients and to present the first results in terms of clinical outcome parameters and risk factors.MATERIALS AND METHODS: A population-based cohort of newly, prospectively, diagnosed cases was initiated between 1991 and 1993. The 2201 patients with IBD (706 had Crohn's disease (CD), 1379 had ulcerative colitis (UC) and 116 had indeterminate colitis) originated from 20 different areas in 11 different European countries and Israel. For the 10-year follow-up of this cohort, electronic data-collecting instruments were made available through an Internet-based website. Data concerning vital status, disease activity, medication use, surgical events, cancer, pregnancy, fertility, quality of life and health-care costs were gathered. A blood sample was obtained from patients and controls to perform genotypic characterization.RESULTS: Thirteen centres from eight European countries and Israel participated. In 958 (316 CD and 642 UC) out of a total of 1505 IBD patients (64%) from these 13 centres, a complete dataset was obtained at follow-up. Even though an increased mortality risk was observed in CD patients 10 years after diagnosis, a benign disease course was observed in this patient group in terms of disease recurrence. A correlation between ASCA and CARD15 variants in CD patients and complicated disease course was observed. A north-south gradient was observed regarding colectomy rates in UC patients. Direct costs were found to be highest in the first year after diagnosis and greater in CD patients than in UC patients, with marked differences between participating countries.CONCLUSIONS: This 10-year clinical follow-up study of a population-based European cohort of IBD patients provides updated information on disease outcome of these patient groups.
AB - OBJECTIVE: To give a general outline of a 10-year clinical follow-up study of a population-based European cohort of inflammatory bowel disease (IBD) patients and to present the first results in terms of clinical outcome parameters and risk factors.MATERIALS AND METHODS: A population-based cohort of newly, prospectively, diagnosed cases was initiated between 1991 and 1993. The 2201 patients with IBD (706 had Crohn's disease (CD), 1379 had ulcerative colitis (UC) and 116 had indeterminate colitis) originated from 20 different areas in 11 different European countries and Israel. For the 10-year follow-up of this cohort, electronic data-collecting instruments were made available through an Internet-based website. Data concerning vital status, disease activity, medication use, surgical events, cancer, pregnancy, fertility, quality of life and health-care costs were gathered. A blood sample was obtained from patients and controls to perform genotypic characterization.RESULTS: Thirteen centres from eight European countries and Israel participated. In 958 (316 CD and 642 UC) out of a total of 1505 IBD patients (64%) from these 13 centres, a complete dataset was obtained at follow-up. Even though an increased mortality risk was observed in CD patients 10 years after diagnosis, a benign disease course was observed in this patient group in terms of disease recurrence. A correlation between ASCA and CARD15 variants in CD patients and complicated disease course was observed. A north-south gradient was observed regarding colectomy rates in UC patients. Direct costs were found to be highest in the first year after diagnosis and greater in CD patients than in UC patients, with marked differences between participating countries.CONCLUSIONS: This 10-year clinical follow-up study of a population-based European cohort of IBD patients provides updated information on disease outcome of these patient groups.
KW - Adult
KW - Artificial Intelligence
KW - Colectomy
KW - Colitis, Ulcerative/economics
KW - Communication
KW - Crohn Disease/economics
KW - Europe/epidemiology
KW - Female
KW - Follow-Up Studies
KW - Genotype
KW - Health Care Costs
KW - Humans
KW - Internet
KW - Israel/epidemiology
KW - Male
KW - Nod2 Signaling Adaptor Protein/genetics
KW - Phenotype
KW - Physician-Patient Relations
KW - Polymorphism, Genetic
KW - Prospective Studies
KW - Recurrence
KW - Risk Factors
U2 - 10.1080/00365520600664250
DO - 10.1080/00365520600664250
M3 - Journal article
C2 - 16782622
SN - 0085-5928
SP - 46
EP - 54
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 243
ER -
