Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

Medicin og biovidenskab

• Benzyl Alcohol 65%
• Caco-2 Cells 85%
• Cell Line 43%
• Dipeptides 93%
• Esterases 12%
• Esters 10%
• glutamylalanine 63%
• Hydrolysis 9%
• Hydrophobic and Hydrophilic Interactions 11%
• Kinetics 7%
• Oligopeptides 100%
• Paraoxon 15%
• Peptides 6%
• Peptidomimetics 15%
• Permeability 8%
• Pharmaceutical Preparations 12%
• Prodrugs 80%
• Quantitative Structure-Activity Relationship 14%

Kemiske forbindelser

• Benzyl Alcohol 45%
• Dipeptide 73%
• Drug 16%
• Ester 6%
• Esterase Inhibitor 16%
• Hydrolysis 6%
• Hydrophobicity 8%
• Modification 5%
• Monolayer 7%
• Oligopeptide 84%
• Paraoxon 14%
• Peptidomimetic 12%
• Permeability 8%
• Plasma 6%
• Prodrug 77%
• Tripeptide 11%