Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

Keyphrases

• Dipeptide 100%
• Prodrug 100%
• Caco-2 Cells 100%
• HPEPT1 100%
• D-Asp 85%
• D-Glu 85%
• Benzyl Alcohol 57%
• Epithelial Transport 57%
• Drug Delivery 14%
• Peptide Carrier 14%
• Low Permeability 14%
• Intestinal Transport 14%
• Hydrophobicity 14%
• Carrier-mediated 14%
• Tripeptide 14%
• Modified Model 14%
• Major Determinants 14%
• Ester Prodrug 14%
• Human Plasma 14%
• Transport Studies 14%
• Peptidomimetics 14%
• Hydrolysis 14%
• Esterase Inhibitor 14%
• Caco-2 Cell Monolayer 14%
• Side Chain 14%
• PH Dependence 14%
• Transport Rate 14%

Biochemistry, Genetics and Molecular Biology

• Dipeptide 100%
• Oligopeptide 100%
• Cell-Free System 50%
• Peptidomimetic 50%
• Intestine Absorption 50%
• Blood Plasma 50%
• Esterase 50%
• Enzymatic Hydrolysis 50%
• Hydrophobicity 50%
• Quantitative Structure-Activity Relationship 50%
• Tripeptide 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Benzyl Alcohol 50%
• Paraoxon 12%