TY - JOUR
T1 - Dihydro-ß-agarofuran Sesquiterpenes and Pentacyclic Triterpenoids from the Root Bark of Osyris lanceolata
AU - Yeboah, Elisabeth M.O.
AU - Majinda, Runner R.T.
AU - Kadziola, Anders
AU - Muller, Alfred
PY - 2010/6/25
Y1 - 2010/6/25
N2 - Three new dihydro-β-agarofuran polyesters, 1α,9β- difuranoyloxy-2-oxodihydro-β-agarofuran (1), 1α,9β- difuranoyloxy-2-oxo-3-enedihydro-β-agarofuran (2), and 1α,9β- difuranoyloxydihydro-β-agarofuran (3), have been isolated from the CHCl3 extract of the root bark of Osyris lanceolata, together with two known pentacylic triterpenoids, 4 and 5. Compounds 1-5 did not scavenge the DPPH radical within 30 min of reaction time. All five compounds displayed antifungal activity against Candida albicans. Compounds 1, 3, 4, and 5 showed antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus and Gram-negative Escherichia coli and Pseudomonas aeruginosa, with 4 and 5 being the most active. Compound 2 displayed weak antibacterial activity only against Escherichia coli.
AB - Three new dihydro-β-agarofuran polyesters, 1α,9β- difuranoyloxy-2-oxodihydro-β-agarofuran (1), 1α,9β- difuranoyloxy-2-oxo-3-enedihydro-β-agarofuran (2), and 1α,9β- difuranoyloxydihydro-β-agarofuran (3), have been isolated from the CHCl3 extract of the root bark of Osyris lanceolata, together with two known pentacylic triterpenoids, 4 and 5. Compounds 1-5 did not scavenge the DPPH radical within 30 min of reaction time. All five compounds displayed antifungal activity against Candida albicans. Compounds 1, 3, 4, and 5 showed antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus and Gram-negative Escherichia coli and Pseudomonas aeruginosa, with 4 and 5 being the most active. Compound 2 displayed weak antibacterial activity only against Escherichia coli.
M3 - Journal article
SN - 0163-3864
VL - 73
SP - 1151
EP - 1155
JO - Journal of Natural Products
JF - Journal of Natural Products
ER -