Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation

J Andersen; C Heilmann; N Jacobsen; Claus Henrik Nielsen; K Bendtzen; K Müller

doi:http://dx.doi.org/10.1038/sj.bmt.1705295

Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation

J Andersen, C Heilmann, N Jacobsen, Claus Henrik Nielsen, K Bendtzen, K Müller

13 Citationer (Scopus)

Abstract

The purpose of this study was to characterize cytokine responses during conditioning in patients undergoing allogeneic stem cell transplantation (SCT) with the aim to identify which markers that may reliably reflect inflammatory activity during conditioning. We investigated inflammatory and anti-inflammatory mediators in plasma samples drawn daily during the conditioning of 20 patients. Soluble tumour necrosis factor alpha receptor I (sTNFRI) increased during the conditioning reflecting the type of conditioning given. Antithymocyte globulin (ATG) was the most potent inducer of sTNFRI (288% increase (median) P=0.002), followed by VP-16 (184%, P=0.03), cyclophosphamide (129%, P=0.03) and total body irradiation (148%, P=0.0005). Administration of i.v. busulfan (Busilvex; BU) was not associated with significant changes in sTNFRI levels. At day 0 (the day of stem cell infusion) the sTNFRI levels were not only elevated compared with baseline (188% increase), P

Originalsprog	Engelsk
Tidsskrift	Bone Marrow Transplantation
Vol/bind	37
Udgave nummer	7
Sider (fra-til)	635-40
Antal sider	6
ISSN	0268-3369
DOI	https://doi.org/10.1038/sj.bmt.1705295
Status	Udgivet - 1 apr. 2006

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http://dx.doi.org/10.1038/sj.bmt.1705295

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abstract = "The purpose of this study was to characterize cytokine responses during conditioning in patients undergoing allogeneic stem cell transplantation (SCT) with the aim to identify which markers that may reliably reflect inflammatory activity during conditioning. We investigated inflammatory and anti-inflammatory mediators in plasma samples drawn daily during the conditioning of 20 patients. Soluble tumour necrosis factor alpha receptor I (sTNFRI) increased during the conditioning reflecting the type of conditioning given. Antithymocyte globulin (ATG) was the most potent inducer of sTNFRI (288% increase (median) P=0.002), followed by VP-16 (184%, P=0.03), cyclophosphamide (129%, P=0.03) and total body irradiation (148%, P=0.0005). Administration of i.v. busulfan (Busilvex; BU) was not associated with significant changes in sTNFRI levels. At day 0 (the day of stem cell infusion) the sTNFRI levels were not only elevated compared with baseline (188% increase), P",

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T1 - Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation

AU - Andersen, J

AU - Heilmann, C

AU - Jacobsen, N

AU - Nielsen, Claus Henrik

AU - Bendtzen, K

AU - Müller, K

PY - 2006/4/1

Y1 - 2006/4/1

N2 - The purpose of this study was to characterize cytokine responses during conditioning in patients undergoing allogeneic stem cell transplantation (SCT) with the aim to identify which markers that may reliably reflect inflammatory activity during conditioning. We investigated inflammatory and anti-inflammatory mediators in plasma samples drawn daily during the conditioning of 20 patients. Soluble tumour necrosis factor alpha receptor I (sTNFRI) increased during the conditioning reflecting the type of conditioning given. Antithymocyte globulin (ATG) was the most potent inducer of sTNFRI (288% increase (median) P=0.002), followed by VP-16 (184%, P=0.03), cyclophosphamide (129%, P=0.03) and total body irradiation (148%, P=0.0005). Administration of i.v. busulfan (Busilvex; BU) was not associated with significant changes in sTNFRI levels. At day 0 (the day of stem cell infusion) the sTNFRI levels were not only elevated compared with baseline (188% increase), P

AB - The purpose of this study was to characterize cytokine responses during conditioning in patients undergoing allogeneic stem cell transplantation (SCT) with the aim to identify which markers that may reliably reflect inflammatory activity during conditioning. We investigated inflammatory and anti-inflammatory mediators in plasma samples drawn daily during the conditioning of 20 patients. Soluble tumour necrosis factor alpha receptor I (sTNFRI) increased during the conditioning reflecting the type of conditioning given. Antithymocyte globulin (ATG) was the most potent inducer of sTNFRI (288% increase (median) P=0.002), followed by VP-16 (184%, P=0.03), cyclophosphamide (129%, P=0.03) and total body irradiation (148%, P=0.0005). Administration of i.v. busulfan (Busilvex; BU) was not associated with significant changes in sTNFRI levels. At day 0 (the day of stem cell infusion) the sTNFRI levels were not only elevated compared with baseline (188% increase), P

U2 - http://dx.doi.org/10.1038/sj.bmt.1705295

DO - http://dx.doi.org/10.1038/sj.bmt.1705295

M3 - Journal article

SN - 0268-3369

VL - 37

SP - 635

EP - 640

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 7

ER -

Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation

Abstract

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