Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression

K W Miskowiak; L Glerup; C Vestbo; C J Harmer; A Reinecke; J Macoveanu; H R Siebner; L V Kessing; M Vinberg

doi:10.1017/s0033291714002542

Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression

K W Miskowiak, L Glerup, C Vestbo, C J Harmer, A Reinecke, J Macoveanu, H R Siebner, L V Kessing, M Vinberg

Institut for Klinisk Medicin

28 Citationer (Scopus)

Abstract

BACKGROUND: Negative cognitive bias and aberrant neural processing of emotional faces are trait-marks of depression. Yet it is unclear whether these changes constitute an endophenotype for depression and are also present in healthy individuals with hereditary risk for depression.

METHOD: Thirty healthy, never-depressed monozygotic (MZ) twins with a co-twin history of depression (high risk group: n = 13) or without co-twin history of depression (low-risk group: n = 17) were enrolled in a functional magnetic resonance imaging (fMRI) study. During fMRI, participants viewed fearful and happy faces while performing a gender discrimination task. After the scan, they were given a faces dot-probe task, a facial expression recognition task and questionnaires assessing mood, personality traits and coping strategies.

RESULTS: High-risk twins showed increased neural response to happy and fearful faces in dorsal anterior cingulate cortex (ACC), dorsomedial prefrontal cortex (dmPFC), pre-supplementary motor area and occipito-parietal regions compared to low-risk twins. They also displayed stronger negative coupling between amygdala and pregenual ACC, dmPFC and temporo-parietal regions during emotional face processing. These task-related changes in neural responses in high-risk twins were accompanied by impaired gender discrimination performance during face processing. They also displayed increased attention vigilance for fearful faces and were slower at recognizing facial expressions relative to low-risk controls. These effects occurred in the absence of differences between groups in mood, subjective state or coping.

CONCLUSIONS: Different neural response and functional connectivity within fronto-limbic and occipito-parietal regions during emotional face processing and enhanced fear vigilance may be key endophenotypes for depression.

Originalsprog	Engelsk
Tidsskrift	Psychological Medicine
Vol/bind	45
Udgave nummer	7
Sider (fra-til)	1447-58
Antal sider	12
ISSN	0033-2917
DOI	https://doi.org/10.1017/s0033291714002542
Status	Udgivet - 28 maj 2015

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10.1017/s0033291714002542

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title = "Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression",

abstract = "BACKGROUND: Negative cognitive bias and aberrant neural processing of emotional faces are trait-marks of depression. Yet it is unclear whether these changes constitute an endophenotype for depression and are also present in healthy individuals with hereditary risk for depression.METHOD: Thirty healthy, never-depressed monozygotic (MZ) twins with a co-twin history of depression (high risk group: n = 13) or without co-twin history of depression (low-risk group: n = 17) were enrolled in a functional magnetic resonance imaging (fMRI) study. During fMRI, participants viewed fearful and happy faces while performing a gender discrimination task. After the scan, they were given a faces dot-probe task, a facial expression recognition task and questionnaires assessing mood, personality traits and coping strategies.RESULTS: High-risk twins showed increased neural response to happy and fearful faces in dorsal anterior cingulate cortex (ACC), dorsomedial prefrontal cortex (dmPFC), pre-supplementary motor area and occipito-parietal regions compared to low-risk twins. They also displayed stronger negative coupling between amygdala and pregenual ACC, dmPFC and temporo-parietal regions during emotional face processing. These task-related changes in neural responses in high-risk twins were accompanied by impaired gender discrimination performance during face processing. They also displayed increased attention vigilance for fearful faces and were slower at recognizing facial expressions relative to low-risk controls. These effects occurred in the absence of differences between groups in mood, subjective state or coping.CONCLUSIONS: Different neural response and functional connectivity within fronto-limbic and occipito-parietal regions during emotional face processing and enhanced fear vigilance may be key endophenotypes for depression.",

keywords = "Adult, Amygdala, Cerebral Cortex, Denmark, Depressive Disorder, Diseases in Twins, Emotions, Endophenotypes, Facial Expression, Facial Recognition, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Registries, Twins, Monozygotic, Journal Article, Research Support, Non-U.S. Gov't, Twin Study",

author = "Miskowiak, {K W} and L Glerup and C Vestbo and Harmer, {C J} and A Reinecke and J Macoveanu and Siebner, {H R} and Kessing, {L V} and M Vinberg",

year = "2015",

month = may,

day = "28",

doi = "10.1017/s0033291714002542",

language = "English",

volume = "45",

pages = "1447--58",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

number = "7",

}

TY - JOUR

T1 - Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression

AU - Miskowiak, K W

AU - Glerup, L

AU - Vestbo, C

AU - Harmer, C J

AU - Reinecke, A

AU - Macoveanu, J

AU - Siebner, H R

AU - Kessing, L V

AU - Vinberg, M

PY - 2015/5/28

Y1 - 2015/5/28

N2 - BACKGROUND: Negative cognitive bias and aberrant neural processing of emotional faces are trait-marks of depression. Yet it is unclear whether these changes constitute an endophenotype for depression and are also present in healthy individuals with hereditary risk for depression.METHOD: Thirty healthy, never-depressed monozygotic (MZ) twins with a co-twin history of depression (high risk group: n = 13) or without co-twin history of depression (low-risk group: n = 17) were enrolled in a functional magnetic resonance imaging (fMRI) study. During fMRI, participants viewed fearful and happy faces while performing a gender discrimination task. After the scan, they were given a faces dot-probe task, a facial expression recognition task and questionnaires assessing mood, personality traits and coping strategies.RESULTS: High-risk twins showed increased neural response to happy and fearful faces in dorsal anterior cingulate cortex (ACC), dorsomedial prefrontal cortex (dmPFC), pre-supplementary motor area and occipito-parietal regions compared to low-risk twins. They also displayed stronger negative coupling between amygdala and pregenual ACC, dmPFC and temporo-parietal regions during emotional face processing. These task-related changes in neural responses in high-risk twins were accompanied by impaired gender discrimination performance during face processing. They also displayed increased attention vigilance for fearful faces and were slower at recognizing facial expressions relative to low-risk controls. These effects occurred in the absence of differences between groups in mood, subjective state or coping.CONCLUSIONS: Different neural response and functional connectivity within fronto-limbic and occipito-parietal regions during emotional face processing and enhanced fear vigilance may be key endophenotypes for depression.

AB - BACKGROUND: Negative cognitive bias and aberrant neural processing of emotional faces are trait-marks of depression. Yet it is unclear whether these changes constitute an endophenotype for depression and are also present in healthy individuals with hereditary risk for depression.METHOD: Thirty healthy, never-depressed monozygotic (MZ) twins with a co-twin history of depression (high risk group: n = 13) or without co-twin history of depression (low-risk group: n = 17) were enrolled in a functional magnetic resonance imaging (fMRI) study. During fMRI, participants viewed fearful and happy faces while performing a gender discrimination task. After the scan, they were given a faces dot-probe task, a facial expression recognition task and questionnaires assessing mood, personality traits and coping strategies.RESULTS: High-risk twins showed increased neural response to happy and fearful faces in dorsal anterior cingulate cortex (ACC), dorsomedial prefrontal cortex (dmPFC), pre-supplementary motor area and occipito-parietal regions compared to low-risk twins. They also displayed stronger negative coupling between amygdala and pregenual ACC, dmPFC and temporo-parietal regions during emotional face processing. These task-related changes in neural responses in high-risk twins were accompanied by impaired gender discrimination performance during face processing. They also displayed increased attention vigilance for fearful faces and were slower at recognizing facial expressions relative to low-risk controls. These effects occurred in the absence of differences between groups in mood, subjective state or coping.CONCLUSIONS: Different neural response and functional connectivity within fronto-limbic and occipito-parietal regions during emotional face processing and enhanced fear vigilance may be key endophenotypes for depression.

KW - Adult

KW - Amygdala

KW - Cerebral Cortex

KW - Denmark

KW - Depressive Disorder

KW - Diseases in Twins

KW - Emotions

KW - Endophenotypes

KW - Facial Expression

KW - Facial Recognition

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Registries

KW - Twins, Monozygotic

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Twin Study

U2 - 10.1017/s0033291714002542

DO - 10.1017/s0033291714002542

M3 - Journal article

C2 - 25382193

SN - 0033-2917

VL - 45

SP - 1447

EP - 1458

JO - Psychological Medicine

JF - Psychological Medicine

IS - 7

ER -

Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression

Abstract

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