Different histopathological subtypes of Hodgkin lymphoma show significantly different levels of FDG uptake

Martin Hutchings; Annika Loft; Mads Hansen; Elisabeth Ralfkiaer; Lena Specht; Martin Hutchings; Annika Loft Jakobsen; Mads Hansen; Elisabeth Ralfkiaer; Lena Specht

doi:10.1002/hon.782

Different histopathological subtypes of Hodgkin lymphoma show significantly different levels of FDG uptake

Martin Hutchings, Annika Loft, Mads Hansen, Elisabeth Ralfkiaer, Lena Specht, Martin Hutchings, Annika Loft Jakobsen, Mads Hansen, Elisabeth Ralfkiaer, Lena Specht

61 Citationer (Scopus)

Abstract

Positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) enables quantitative analysis of metabolic activity. This study investigated standardized uptake value (SUV) levels in the different histopathological subtypes of Hodgkin lymphoma (HL). Sixty patients with newly diagnosed HL underwent staging FDG-PET/CT after lymph node biopsy. Maximum SUV in each patient (SUV(max/total)) and in each affected region or organ (SUV(max)) were recorded. Mean SUV(max/total) was 9.3 g/ml in seven nodular lymphocyte predominance (NLP) patients, 16.3 g/ml in 38 nodular sclerosis (NS) patients, 20.8 g/ml in 11 mixed cellularity (MC) patients, and 19.5 g/ml in four patients with unclassified classical HL (CHL-NOS), (ANOVA, p = 0.011). Out of 780 sites (600 lymph node regions plus 180 organs), 208 sites were found to be affected with HL. Mean SUV(max) was 8.3 g/ml in the 12 sites with NLP, 11.2 g/ml in the 147 sites affected with NS, 14.6 g/ml in the 36 sites with MC, and 13.1 g/ml in the 13 sites with CHL-NOS (ANOVA, p = 0.002). There is a significant difference in FDG/glucose uptake between the different histopathological subtypes of HL.

Originalsprog	Engelsk
Tidsskrift	Hematological Oncology
Vol/bind	24
Udgave nummer	3
Sider (fra-til)	146-50
Antal sider	5
ISSN	0278-0232
DOI	https://doi.org/10.1002/hon.782 https://doi.org/10.1002/hon.782
Status	Udgivet - 1 sep. 2006

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title = "Different histopathological subtypes of Hodgkin lymphoma show significantly different levels of FDG uptake",

abstract = "Positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) enables quantitative analysis of metabolic activity. This study investigated standardized uptake value (SUV) levels in the different histopathological subtypes of Hodgkin lymphoma (HL). Sixty patients with newly diagnosed HL underwent staging FDG-PET/CT after lymph node biopsy. Maximum SUV in each patient (SUV(max/total)) and in each affected region or organ (SUV(max)) were recorded. Mean SUV(max/total) was 9.3 g/ml in seven nodular lymphocyte predominance (NLP) patients, 16.3 g/ml in 38 nodular sclerosis (NS) patients, 20.8 g/ml in 11 mixed cellularity (MC) patients, and 19.5 g/ml in four patients with unclassified classical HL (CHL-NOS), (ANOVA, p = 0.011). Out of 780 sites (600 lymph node regions plus 180 organs), 208 sites were found to be affected with HL. Mean SUV(max) was 8.3 g/ml in the 12 sites with NLP, 11.2 g/ml in the 147 sites affected with NS, 14.6 g/ml in the 36 sites with MC, and 13.1 g/ml in the 13 sites with CHL-NOS (ANOVA, p = 0.002). There is a significant difference in FDG/glucose uptake between the different histopathological subtypes of HL.",

author = "Martin Hutchings and Annika Loft and Mads Hansen and Elisabeth Ralfkiaer and Lena Specht and Martin Hutchings and Jakobsen, {Annika Loft} and Mads Hansen and Elisabeth Ralfkiaer and Lena Specht",

note = "Keywords: Adult; Female; Fluorodeoxyglucose F18; Hodgkin Disease; Humans; Lymph Nodes; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity",

year = "2006",

month = sep,

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doi = "10.1002/hon.782",

language = "English",

volume = "24",

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T1 - Different histopathological subtypes of Hodgkin lymphoma show significantly different levels of FDG uptake

AU - Hutchings, Martin

AU - Loft, Annika

AU - Hansen, Mads

AU - Ralfkiaer, Elisabeth

AU - Specht, Lena

AU - Hutchings, Martin

AU - Jakobsen, Annika Loft

AU - Hansen, Mads

AU - Ralfkiaer, Elisabeth

AU - Specht, Lena

N1 - Keywords: Adult; Female; Fluorodeoxyglucose F18; Hodgkin Disease; Humans; Lymph Nodes; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) enables quantitative analysis of metabolic activity. This study investigated standardized uptake value (SUV) levels in the different histopathological subtypes of Hodgkin lymphoma (HL). Sixty patients with newly diagnosed HL underwent staging FDG-PET/CT after lymph node biopsy. Maximum SUV in each patient (SUV(max/total)) and in each affected region or organ (SUV(max)) were recorded. Mean SUV(max/total) was 9.3 g/ml in seven nodular lymphocyte predominance (NLP) patients, 16.3 g/ml in 38 nodular sclerosis (NS) patients, 20.8 g/ml in 11 mixed cellularity (MC) patients, and 19.5 g/ml in four patients with unclassified classical HL (CHL-NOS), (ANOVA, p = 0.011). Out of 780 sites (600 lymph node regions plus 180 organs), 208 sites were found to be affected with HL. Mean SUV(max) was 8.3 g/ml in the 12 sites with NLP, 11.2 g/ml in the 147 sites affected with NS, 14.6 g/ml in the 36 sites with MC, and 13.1 g/ml in the 13 sites with CHL-NOS (ANOVA, p = 0.002). There is a significant difference in FDG/glucose uptake between the different histopathological subtypes of HL.

AB - Positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) enables quantitative analysis of metabolic activity. This study investigated standardized uptake value (SUV) levels in the different histopathological subtypes of Hodgkin lymphoma (HL). Sixty patients with newly diagnosed HL underwent staging FDG-PET/CT after lymph node biopsy. Maximum SUV in each patient (SUV(max/total)) and in each affected region or organ (SUV(max)) were recorded. Mean SUV(max/total) was 9.3 g/ml in seven nodular lymphocyte predominance (NLP) patients, 16.3 g/ml in 38 nodular sclerosis (NS) patients, 20.8 g/ml in 11 mixed cellularity (MC) patients, and 19.5 g/ml in four patients with unclassified classical HL (CHL-NOS), (ANOVA, p = 0.011). Out of 780 sites (600 lymph node regions plus 180 organs), 208 sites were found to be affected with HL. Mean SUV(max) was 8.3 g/ml in the 12 sites with NLP, 11.2 g/ml in the 147 sites affected with NS, 14.6 g/ml in the 36 sites with MC, and 13.1 g/ml in the 13 sites with CHL-NOS (ANOVA, p = 0.002). There is a significant difference in FDG/glucose uptake between the different histopathological subtypes of HL.

U2 - 10.1002/hon.782

DO - 10.1002/hon.782

M3 - Journal article

C2 - 16729353

SN - 0278-0232

VL - 24

SP - 146

EP - 150

JO - Hematological Oncology

JF - Hematological Oncology

IS - 3

ER -

Different histopathological subtypes of Hodgkin lymphoma show significantly different levels of FDG uptake

Abstract

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