@article{8c7e1210a0da11dd86a6000ea68e967b,
title = "Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients",
abstract = "The T cell response to different Leishmania donovani antigens was investigated using peripheral blood mononuclear cells (PBMC) from Kenyans cured of visceral leishmaniasis and non-exposed Danes. Crude promastigote and amastigote antigens both induced proliferation and interferon-gamma (IFN-gamma) production in PBMC from cured patients, while cells from non-exposed donors gave weak responses. A similar pattern was induced by lipophosphoglycan-associated protein (LPGAP). By contrast, the major surface protease of Leishmania, gp63, induced only a weak proliferative response without IFN-gamma production in five of 17 samples from cured patients. Four of the five responding cultures produced IL-4, i.e. the response to this antigen was of the Th2 type. Furthermore, sera from acutely ill visceral leishmaniasis patients contained high levels of IgG antibodies to gp63. The Th2-like response to gp63 in patients cured of visceral leishmaniasis differs from the Th1-like response to the same antigen observed in patients cured of cutaneous leishmaniasis.",
author = "Kurtzhals, {J A} and Hey, {A S} and A Jardim and M Kemp and Schaefer, {K U} and Odera, {E O} and Christensen, {C B} and Githure, {J I} and Olafson, {R W} and Theander, {T G}",
note = "Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Glycosphingolipids; Humans; Interferon Type II; Interleukin-4; Leishmania donovani; Leishmaniasis, Visceral; Lymphocyte Activation; Metalloendopeptidases; Protozoan Proteins; T-Lymphocyte Subsets; T-Lymphocytes; T-Lymphocytes, Helper-Inducer",
year = "1994",
language = "English",
volume = "96",
pages = "416--21",
journal = "Clinical and Experimental Immunology, Supplement",
issn = "0964-2536",
publisher = "Wiley-Blackwell",
number = "3",
}