TY - JOUR
T1 - Diagnostic value of exercise-induced changes in circulating high sensitive troponin T in stable chest pain patients
AU - Mouridsen, Mette Rauhe
AU - Nielsen, Olav Wendelboe
AU - Pedersen, Ole Dyg
AU - Carlsen, Christian Malchau
AU - Intzilakis, Theodoros
AU - Binici, Zeynep
AU - Sajadieh, Ahmad
PY - 2013/12
Y1 - 2013/12
N2 - Objective: We investigated the diagnostic value of exercise-induced increase in cardiac Troponin T (cTnT) in stable chest pain subjects. Methods: CTnT was measured before and 20h after an exercise test in 157 subjects suspected of coronary artery disease (CAD). Results: CAD subjects (n=41) had higher baseline cTnT levels compared to non-CAD subjects (n=116), 6.39ng/l and 3.00ng/l, respectively, p<0.0001, and were more likely to increase in cTnT (70.7% versus 27.6%, p<0.0001). Net Reclassification Index for the combined variable was 19%, p=0.02. Conclusions: Exercise-induced increase in cTnT was found to be associated with CAD and cTnT measurements improved the diagnostic evaluation.
AB - Objective: We investigated the diagnostic value of exercise-induced increase in cardiac Troponin T (cTnT) in stable chest pain subjects. Methods: CTnT was measured before and 20h after an exercise test in 157 subjects suspected of coronary artery disease (CAD). Results: CAD subjects (n=41) had higher baseline cTnT levels compared to non-CAD subjects (n=116), 6.39ng/l and 3.00ng/l, respectively, p<0.0001, and were more likely to increase in cTnT (70.7% versus 27.6%, p<0.0001). Net Reclassification Index for the combined variable was 19%, p=0.02. Conclusions: Exercise-induced increase in cTnT was found to be associated with CAD and cTnT measurements improved the diagnostic evaluation.
U2 - 10.3109/1354750x.2013.854835
DO - 10.3109/1354750x.2013.854835
M3 - Journal article
C2 - 24188347
SN - 1354-750X
VL - 18
SP - 726
EP - 733
JO - Biomarkers
JF - Biomarkers
IS - 8
ER -