Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Alan J Thompson; Brenda L Banwell; Frederik Barkhof; William M Carroll; Timothy Coetzee; Giancarlo Comi; Jorge Correale; Franz Fazekas; Massimo Filippi; Mark S Freedman; Kazuo Fujihara; Steven L Galetta; Hans Peter Hartung; Ludwig Kappos; Fred D Lublin; Ruth Ann Marrie; Aaron E Miller; David H Miller; Xavier Montalban; Ellen M Mowry; Per Soelberg Sorensen; Mar Tintoré; Anthony L Traboulsee; Maria Trojano; Bernard M J Uitdehaag; Sandra Vukusic; Emmanuelle Waubant; Brian G Weinshenker; Stephen C Reingold; Jeffrey A Cohen

doi:10.1016/S1474-4422(17)30470-2

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Alan J Thompson, Brenda L Banwell, Frederik Barkhof, William M Carroll, Timothy Coetzee, Giancarlo Comi, Jorge Correale, Franz Fazekas, Massimo Filippi, Mark S Freedman, Kazuo Fujihara, Steven L Galetta, Hans Peter Hartung, Ludwig Kappos, Fred D Lublin, Ruth Ann Marrie, Aaron E Miller, David H Miller, Xavier Montalban, Ellen M MowryPer Soelberg Sorensen, Mar Tintoré, Anthony L Traboulsee, Maria Trojano, Bernard M J Uitdehaag, Sandra Vukusic, Emmanuelle Waubant, Brian G Weinshenker, Stephen C Reingold, Jeffrey A Cohen

Institut for Klinisk Medicin

1528 Citationer (Scopus)

Abstract

The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The following changes were made: in patients with a typical clinically isolated syndrome and clinical or MRI demonstration of dissemination in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple sclerosis; symptomatic lesions can be used to demonstrate dissemination in space or time in patients with supratentorial, infratentorial, or spinal cord syndrome; and cortical lesions can be used to demonstrate dissemination in space. Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers.

Originalsprog	Engelsk
Tidsskrift	Lancet Neurology
Vol/bind	17
Udgave nummer	2
Sider (fra-til)	162-173
ISSN	1474-4422
DOI	https://doi.org/10.1016/S1474-4422(17)30470-2
Status	Udgivet - feb. 2018

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10.1016/S1474-4422(17)30470-2

Citationsformater

Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., Fujihara, K., Galetta, S. L., Hartung, H. P., Kappos, L., Lublin, F. D., Marrie, R. A., Miller, A. E., Miller, D. H., Montalban, X., ... Cohen, J. A. (2018). Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurology, 17(2), 162-173. https://doi.org/10.1016/S1474-4422(17)30470-2

Thompson, AJ, Banwell, BL, Barkhof, F, Carroll, WM, Coetzee, T, Comi, G, Correale, J, Fazekas, F, Filippi, M, Freedman, MS, Fujihara, K, Galetta, SL, Hartung, HP, Kappos, L, Lublin, FD, Marrie, RA, Miller, AE, Miller, DH, Montalban, X, Mowry, EM, Sorensen, PS, Tintoré, M, Traboulsee, AL, Trojano, M, Uitdehaag, BMJ, Vukusic, S, Waubant, E, Weinshenker, BG, Reingold, SC & Cohen, JA 2018, 'Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria', Lancet Neurology, bind 17, nr. 2, s. 162-173. https://doi.org/10.1016/S1474-4422(17)30470-2

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title = "Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria",

abstract = "The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The following changes were made: in patients with a typical clinically isolated syndrome and clinical or MRI demonstration of dissemination in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple sclerosis; symptomatic lesions can be used to demonstrate dissemination in space or time in patients with supratentorial, infratentorial, or spinal cord syndrome; and cortical lesions can be used to demonstrate dissemination in space. Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers.",

keywords = "Adult, Aged, Cerebral Cortex/pathology, Demyelinating Diseases/diagnosis, Humans, Magnetic Resonance Imaging, Middle Aged, Multiple Sclerosis/diagnosis, Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging, Neurologic Examination, Oligoclonal Bands/cerebrospinal fluid, Spinal Cord/pathology",

author = "Thompson, {Alan J} and Banwell, {Brenda L} and Frederik Barkhof and Carroll, {William M} and Timothy Coetzee and Giancarlo Comi and Jorge Correale and Franz Fazekas and Massimo Filippi and Freedman, {Mark S} and Kazuo Fujihara and Galetta, {Steven L} and Hartung, {Hans Peter} and Ludwig Kappos and Lublin, {Fred D} and Marrie, {Ruth Ann} and Miller, {Aaron E} and Miller, {David H} and Xavier Montalban and Mowry, {Ellen M} and Sorensen, {Per Soelberg} and Mar Tintor{\'e} and Traboulsee, {Anthony L} and Maria Trojano and Uitdehaag, {Bernard M J} and Sandra Vukusic and Emmanuelle Waubant and Weinshenker, {Brian G} and Reingold, {Stephen C} and Cohen, {Jeffrey A}",

year = "2018",

month = feb,

doi = "10.1016/S1474-4422(17)30470-2",

language = "English",

volume = "17",

pages = "162--173",

journal = "The Lancet Neurology",

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T1 - Diagnosis of multiple sclerosis

T2 - 2017 revisions of the McDonald criteria

AU - Thompson, Alan J

AU - Banwell, Brenda L

AU - Barkhof, Frederik

AU - Carroll, William M

AU - Coetzee, Timothy

AU - Comi, Giancarlo

AU - Correale, Jorge

AU - Fazekas, Franz

AU - Filippi, Massimo

AU - Freedman, Mark S

AU - Fujihara, Kazuo

AU - Galetta, Steven L

AU - Hartung, Hans Peter

AU - Kappos, Ludwig

AU - Lublin, Fred D

AU - Marrie, Ruth Ann

AU - Miller, Aaron E

AU - Miller, David H

AU - Montalban, Xavier

AU - Mowry, Ellen M

AU - Sorensen, Per Soelberg

AU - Tintoré, Mar

AU - Traboulsee, Anthony L

AU - Trojano, Maria

AU - Uitdehaag, Bernard M J

AU - Vukusic, Sandra

AU - Waubant, Emmanuelle

AU - Weinshenker, Brian G

AU - Reingold, Stephen C

AU - Cohen, Jeffrey A

PY - 2018/2

Y1 - 2018/2

N2 - The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The following changes were made: in patients with a typical clinically isolated syndrome and clinical or MRI demonstration of dissemination in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple sclerosis; symptomatic lesions can be used to demonstrate dissemination in space or time in patients with supratentorial, infratentorial, or spinal cord syndrome; and cortical lesions can be used to demonstrate dissemination in space. Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers.

AB - The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The following changes were made: in patients with a typical clinically isolated syndrome and clinical or MRI demonstration of dissemination in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple sclerosis; symptomatic lesions can be used to demonstrate dissemination in space or time in patients with supratentorial, infratentorial, or spinal cord syndrome; and cortical lesions can be used to demonstrate dissemination in space. Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers.

KW - Adult

KW - Aged

KW - Cerebral Cortex/pathology

KW - Demyelinating Diseases/diagnosis

KW - Humans

KW - Magnetic Resonance Imaging

KW - Middle Aged

KW - Multiple Sclerosis/diagnosis

KW - Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging

KW - Neurologic Examination

KW - Oligoclonal Bands/cerebrospinal fluid

KW - Spinal Cord/pathology

U2 - 10.1016/S1474-4422(17)30470-2

DO - 10.1016/S1474-4422(17)30470-2

M3 - Review

C2 - 29275977

SN - 1474-4422

VL - 17

SP - 162

EP - 173

JO - The Lancet Neurology

JF - The Lancet Neurology

IS - 2

ER -

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Abstract

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