TY - JOUR
T1 - Diagnosis of intraductal papillary mucinous neoplasm using endoscopic ultrasound guided microbiopsies
T2 - A case report
AU - Rift, Charlotte Vestrup
AU - Kovacevic, Bojan
AU - Karstensen, John Gásdal
AU - Plougmann, Julie
AU - Klausen, Pia
AU - Toxværd, Anders
AU - Kalaitzakis, Evangelos
AU - Hansen, Carsten Palnæs
AU - Hasselby, Jane Preuss
AU - Vilmann, Peter
PY - 2018
Y1 - 2018
N2 - Pancreatic cysts are increasingly diagnosed due to expanding use of cross-sectional imaging, but current diagnostic modalities have limited diagnostic accuracy. Recently, a novel through-the-needle microbiopsy forceps has become available, offering the possibility of obtaining cyst-wall biopsies. We present a case of 41-year-old male with chronic pancreatitis and a 2-cm pancreatic cyst, initially considered a pseudocyst. Subsequently, endoscopic ultrasound guided microbiopsies were successfully obtained, which surprisingly revealed an intraductal papillary mucinous neoplasm of mixed subtype with low grade dysplasia. In conclusion, obtaining biopsies from the wall of the pancreatic cystic lesions with this novel instrument is feasible and, as demonstrated in this case, can possibly alter the clinical outcome. Microbiopsies offered enough cellular material, allowing supplemental gene mutation analysis, which combined with other modalities could lead to a more individual approach when treating pancreatic cysts. However, prospective studies are warranted before routine clinical implementation.
AB - Pancreatic cysts are increasingly diagnosed due to expanding use of cross-sectional imaging, but current diagnostic modalities have limited diagnostic accuracy. Recently, a novel through-the-needle microbiopsy forceps has become available, offering the possibility of obtaining cyst-wall biopsies. We present a case of 41-year-old male with chronic pancreatitis and a 2-cm pancreatic cyst, initially considered a pseudocyst. Subsequently, endoscopic ultrasound guided microbiopsies were successfully obtained, which surprisingly revealed an intraductal papillary mucinous neoplasm of mixed subtype with low grade dysplasia. In conclusion, obtaining biopsies from the wall of the pancreatic cystic lesions with this novel instrument is feasible and, as demonstrated in this case, can possibly alter the clinical outcome. Microbiopsies offered enough cellular material, allowing supplemental gene mutation analysis, which combined with other modalities could lead to a more individual approach when treating pancreatic cysts. However, prospective studies are warranted before routine clinical implementation.
U2 - 10.4253/wjge.v10.i7.125
DO - 10.4253/wjge.v10.i7.125
M3 - Journal article
C2 - 30079140
SN - 1948-5190
VL - 10
SP - 125
EP - 129
JO - World Journal of Gastrointestinal Endoscopy
JF - World Journal of Gastrointestinal Endoscopy
IS - 7
ER -