Development of the liver: Insights into organ and tissue morphogenesis

TY - JOUR

T1 - Development of the liver: Insights into organ and tissue morphogenesis

AU - Ober, Elke A.

AU - Lemaigre, Frederic P.

N1 - M1 - Copyright (C) 2018 U.S. National Library of Medicine. MEDLINE AN 2019412393(Journal; Article; (JOURNAL ARTICLE); General Review; (REVIEW))

PY - 2018/5

Y1 - 2018/5

N2 - Recent development of improved tools and methods to analyse tissues at the three-dimensional level has expanded our capacity to investigate morphogenesis of foetal liver. Here, we review the key morphogenetic steps during liver development, from the prehepatic endoderm stage to the postnatal period, and consider several model organisms while focussing on the mammalian liver. We first discuss how the liver buds out of the endoderm and gives rise to an asymmetric liver. We next outline the mechanisms driving liver and lobe growth, and review morphogenesis of the intra- and extrahepatic bile ducts; morphogenetic responses of the biliary tract to liver injury are discussed. Finally, we describe the mechanisms driving formation of the vasculature, namely venous and arterial vessels, as well as sinusoids.

AB - Recent development of improved tools and methods to analyse tissues at the three-dimensional level has expanded our capacity to investigate morphogenesis of foetal liver. Here, we review the key morphogenetic steps during liver development, from the prehepatic endoderm stage to the postnatal period, and consider several model organisms while focussing on the mammalian liver. We first discuss how the liver buds out of the endoderm and gives rise to an asymmetric liver. We next outline the mechanisms driving liver and lobe growth, and review morphogenesis of the intra- and extrahepatic bile ducts; morphogenetic responses of the biliary tract to liver injury are discussed. Finally, we describe the mechanisms driving formation of the vasculature, namely venous and arterial vessels, as well as sinusoids.

KW - bile duct

KW - cholangiocyte

KW - development

KW - hepatocyte

KW - liver

KW - liver growth

KW - morphogenesis

KW - organ asymmetry

KW - sinusoidal endothelial cell

KW - tissue architecture

U2 - 10.1016/j.jhep.2018.01.005

DO - 10.1016/j.jhep.2018.01.005

M3 - Review

C2 - 29339113

SN - 1600-0641

VL - 68

SP - 1049

EP - 1062

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 5

ER -