TY - JOUR
T1 - Development of new predictive markers for endocrine therapy and resistance in breast cancer
AU - Henriksen, Katrine L
AU - Sonne-Hansen, Katrine
AU - Kirkegaard, Tove
AU - Frogne, Thomas
AU - Lykkesfeldt, Anne E
PY - 2008
Y1 - 2008
N2 - Today, the decision to treat breast cancer patients with endocrine therapy relies solely on tumor expression of two predictive factors, the estrogen receptor and the progesterone receptor. Expression of these hormone receptors are, however, not a guarantee for a response to treatment and patients who experience response at first may become resistant after prolonged treatment. This paper describes the use of preclinical models to identify mechanisms and new markers for endocrine sensitivity and resistance and the translation of these data to clinical utility.
AB - Today, the decision to treat breast cancer patients with endocrine therapy relies solely on tumor expression of two predictive factors, the estrogen receptor and the progesterone receptor. Expression of these hormone receptors are, however, not a guarantee for a response to treatment and patients who experience response at first may become resistant after prolonged treatment. This paper describes the use of preclinical models to identify mechanisms and new markers for endocrine sensitivity and resistance and the translation of these data to clinical utility.
KW - Aromatase Inhibitors
KW - Breast Neoplasms
KW - Estrogen Receptor Modulators
KW - Female
KW - Humans
KW - Tumor Markers, Biological
U2 - 10.1080/02841860802026993
DO - 10.1080/02841860802026993
M3 - Journal article
C2 - 18465351
SN - 1502-3850
VL - 47
SP - 795
EP - 801
JO - Acta oncologica (Stockholm, Sweden)
JF - Acta oncologica (Stockholm, Sweden)
IS - 4
ER -