Development of new predictive markers for endocrine therapy and resistance in breast cancer

Katrine L Henriksen; Katrine Sonne-Hansen; Tove Kirkegaard; Thomas Frogne; Anne E Lykkesfeldt

doi:10.1080/02841860802026993

Development of new predictive markers for endocrine therapy and resistance in breast cancer

Katrine L Henriksen, Katrine Sonne-Hansen, Tove Kirkegaard, Thomas Frogne, Anne E Lykkesfeldt

6 Citationer (Scopus)

Abstract

Today, the decision to treat breast cancer patients with endocrine therapy relies solely on tumor expression of two predictive factors, the estrogen receptor and the progesterone receptor. Expression of these hormone receptors are, however, not a guarantee for a response to treatment and patients who experience response at first may become resistant after prolonged treatment. This paper describes the use of preclinical models to identify mechanisms and new markers for endocrine sensitivity and resistance and the translation of these data to clinical utility.

Originalsprog	Engelsk
Tidsskrift	Acta oncologica (Stockholm, Sweden)
Vol/bind	47
Udgave nummer	4
Sider (fra-til)	795-801
Antal sider	7
DOI	https://doi.org/10.1080/02841860802026993
Status	Udgivet - 2008
Udgivet eksternt	Ja

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10.1080/02841860802026993

Citationsformater

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abstract = "Today, the decision to treat breast cancer patients with endocrine therapy relies solely on tumor expression of two predictive factors, the estrogen receptor and the progesterone receptor. Expression of these hormone receptors are, however, not a guarantee for a response to treatment and patients who experience response at first may become resistant after prolonged treatment. This paper describes the use of preclinical models to identify mechanisms and new markers for endocrine sensitivity and resistance and the translation of these data to clinical utility.",

keywords = "Aromatase Inhibitors, Breast Neoplasms, Estrogen Receptor Modulators, Female, Humans, Tumor Markers, Biological",

author = "Henriksen, {Katrine L} and Katrine Sonne-Hansen and Tove Kirkegaard and Thomas Frogne and Lykkesfeldt, {Anne E}",

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AU - Henriksen, Katrine L

AU - Sonne-Hansen, Katrine

AU - Kirkegaard, Tove

AU - Frogne, Thomas

AU - Lykkesfeldt, Anne E

PY - 2008

Y1 - 2008

N2 - Today, the decision to treat breast cancer patients with endocrine therapy relies solely on tumor expression of two predictive factors, the estrogen receptor and the progesterone receptor. Expression of these hormone receptors are, however, not a guarantee for a response to treatment and patients who experience response at first may become resistant after prolonged treatment. This paper describes the use of preclinical models to identify mechanisms and new markers for endocrine sensitivity and resistance and the translation of these data to clinical utility.

AB - Today, the decision to treat breast cancer patients with endocrine therapy relies solely on tumor expression of two predictive factors, the estrogen receptor and the progesterone receptor. Expression of these hormone receptors are, however, not a guarantee for a response to treatment and patients who experience response at first may become resistant after prolonged treatment. This paper describes the use of preclinical models to identify mechanisms and new markers for endocrine sensitivity and resistance and the translation of these data to clinical utility.

KW - Aromatase Inhibitors

KW - Breast Neoplasms

KW - Estrogen Receptor Modulators

KW - Female

KW - Humans

KW - Tumor Markers, Biological

U2 - 10.1080/02841860802026993

DO - 10.1080/02841860802026993

M3 - Journal article

C2 - 18465351

SN - 0001-6357

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JO - Acta Odontologica Scandinavica

JF - Acta Odontologica Scandinavica

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ER -

Development of new predictive markers for endocrine therapy and resistance in breast cancer

Abstract

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