Development and descent of the testis in relation to cryptorchidism

Helena E Virtanen; Dina Cortes; Ewa Rajpert-De Meyts; E Martin Ritzén; Agneta Nordenskjöld; Niels E Skakkebaek; Jorma Toppari

doi:10.1111/j.1651-2227.2007.00244.x

Development and descent of the testis in relation to cryptorchidism

Helena E Virtanen, Dina Cortes, Ewa Rajpert-De Meyts, E Martin Ritzén, Agneta Nordenskjöld, Niels E Skakkebaek, Jorma Toppari

Institut for Klinisk Medicin

70 Citationer (Scopus)

Abstract

The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.

Originalsprog	Engelsk
Tidsskrift	Acta Paediatrica
Vol/bind	96
Udgave nummer	5
Sider (fra-til)	622-7
Antal sider	6
ISSN	0803-5253
DOI	https://doi.org/10.1111/j.1651-2227.2007.00244.x
Status	Udgivet - 1 maj 2007

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10.1111/j.1651-2227.2007.00244.x

Citationsformater

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abstract = "The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.",

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T1 - Development and descent of the testis in relation to cryptorchidism

AU - Virtanen, Helena E

AU - Cortes, Dina

AU - Rajpert-De Meyts, Ewa

AU - Ritzén, E Martin

AU - Nordenskjöld, Agneta

AU - Skakkebaek, Niels E

AU - Toppari, Jorma

PY - 2007/5/1

Y1 - 2007/5/1

N2 - The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.

AB - The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.

KW - Animals

KW - Cell Differentiation

KW - Child

KW - Cryptorchidism

KW - Humans

KW - Infant

KW - Insulin

KW - Leydig Cells

KW - Male

KW - Models, Animal

KW - Proteins

KW - Testis

U2 - 10.1111/j.1651-2227.2007.00244.x

DO - 10.1111/j.1651-2227.2007.00244.x

M3 - Journal article

C2 - 17462055

SN - 0803-5253

VL - 96

SP - 622

EP - 627

JO - Acta Paediatrica, International Journal of Paediatrics, Supplement

JF - Acta Paediatrica, International Journal of Paediatrics, Supplement

IS - 5

ER -

Development and descent of the testis in relation to cryptorchidism

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