Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

Maximilian Karl; Jukka Rantanen; Thomas Rades

doi:10.3390/pharmaceutics11120670

Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

Maximilian Karl, Jukka Rantanen, Thomas Rades

1 Citationer (Scopus)

Abstract

Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.

Originalsprog	Engelsk
Tidsskrift	Pharmaceutics
Vol/bind	11
Udgave nummer	12
ISSN	1999-4923
DOI	https://doi.org/10.3390/pharmaceutics11120670
Status	Udgivet - 6 dec. 2019

Adgang til dokumentet

10.3390/pharmaceutics11120670

Citationsformater

@article{c747f6c8092141d4889d09bddcfd3de4,

title = "Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation",

abstract = "Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.",

author = "Maximilian Karl and Jukka Rantanen and Thomas Rades",

year = "2019",

month = dec,

day = "6",

doi = "10.3390/pharmaceutics11120670",

language = "English",

volume = "11",

journal = "Pharmaceutics",

issn = "1999-4923",

publisher = "MDPI AG",

number = "12",

}

TY - JOUR

T1 - Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

AU - Karl, Maximilian

AU - Rantanen, Jukka

AU - Rades, Thomas

PY - 2019/12/6

Y1 - 2019/12/6

N2 - Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.

AB - Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.

U2 - 10.3390/pharmaceutics11120670

DO - 10.3390/pharmaceutics11120670

M3 - Journal article

SN - 1999-4923

VL - 11

JO - Pharmaceutics

JF - Pharmaceutics

IS - 12

ER -

Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater