Determinants of occurrence and survival after sudden cardiac arrest–A European perspective: The ESCAPE-NET project

TY - JOUR

T1 - Determinants of occurrence and survival after sudden cardiac arrest–A European perspective

T2 - The ESCAPE-NET project

AU - Empana, Jean Philippe

AU - Blom, Marieke T.

AU - Bӧttiger, Bernd W.

AU - Dagres, Nikolaos

AU - Dekker, Jacqueline M.

AU - Gislason, Gunnar

AU - Jouven, Xavier

AU - Meitinger, Thomas

AU - Ristagno, Giuseppe

AU - Schwartz, Peter J.

AU - Jonsson, Martin

AU - Tfelt-Hansen, Jacob

AU - Truhlar, Anatolij

AU - Tan, Hanno L.

AU - on behalf of the ESCAPE-NET Investigators

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Aims The ESCAPE-NET project (“European Sudden Cardiac Arrest network– towards Prevention, Education and New Effective Treatments”) aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. Methods This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. Results The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum München (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. Conclusion ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project.

AB - Aims The ESCAPE-NET project (“European Sudden Cardiac Arrest network– towards Prevention, Education and New Effective Treatments”) aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. Methods This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. Results The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum München (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. Conclusion ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project.

KW - Automated external defibrillator

KW - Genetics

KW - Resuscitation

KW - Sudden cardiac arrest

KW - Out-of-Hospital Cardiac Arrest/etiology

KW - Risk Assessment

KW - Comorbidity

KW - Humans

KW - Risk Factors

KW - Death, Sudden, Cardiac/epidemiology

KW - Population Surveillance/methods

KW - Emergency Medical Services/statistics & numerical data

KW - Europe/epidemiology

KW - Cohort Studies

KW - Databases, Factual

UR - http://www.scopus.com/inward/record.url?scp=85039729136&partnerID=8YFLogxK

U2 - 10.1016/j.resuscitation.2017.12.011

DO - 10.1016/j.resuscitation.2017.12.011

M3 - Journal article

C2 - 29246744

AN - SCOPUS:85039729136

SN - 0300-9572

VL - 124

SP - 7

EP - 13

JO - Resuscitation

JF - Resuscitation

ER -