Design and Synthesis of Epigenetic Drugs: Targeting the Histone Demethylase KDM4C

Biochemistry, Genetics and Molecular Biology

• Epigenetics 100%
• Histone 100%
• Drug Targeting 100%
• Demethylase 100%
• Enzyme 80%
• Hydrogen/Deuterium Exchange Mass Spectrometry 40%
• Oxygenase 40%
• Active Site 40%
• Epigenetics 20%
• Binding Site 20%
• N-Terminus 20%
• Gene Expression 20%
• C-Terminus 20%
• Epigenomics 20%
• Transcriptome 20%
• Mass Spectrometry 20%
• DNA Methylation 20%
• Phage Display 20%
• Sequence Homology 20%
• Cyclic Peptide 20%

Keyphrases

• Drug Target 100%
• Epigenetic Drugs 100%
• Histone Demethylase 100%
• KDM4C 100%
• Oxygenase 28%
• Hydrogen-deuterium Exchange Mass Spectrometry 28%
• Active Sites 28%
• Small Molecules 14%
• Cyclic Peptide 14%
• Histone-modifying Enzymes 14%
• Transcriptome 14%
• Heterocyclic Rings 14%
• Histone Peptides 14%
• Phage Display Screening 14%
• Novel Scaffolds 14%
• Off-target Effects 14%
• Histone Proteins 14%
• Mass Spectrometry Analysis 14%
• Gene Expression 14%
• Mode of Inhibition 14%
• Substrate Competition 14%
• Enzyme Class 14%
• Binding Site 14%
• Epigenetics 14%
• Peptide Substrate 14%
• DNA Methylation (DNAm) 14%
• Competition Experiments 14%
• Sequence Homology 14%
• DNA-modifying Enzyme 14%
• Binder 14%