Dense distributed processing in a hindlimb scratch motor network

Robertas Guzulaitis; Jørn Dybkjær Hounsgaard

doi:10.1523/JNEUROSCI.1079-14.2014

Dense distributed processing in a hindlimb scratch motor network

Robertas Guzulaitis, Jørn Dybkjær Hounsgaard

Neuronal Signalling

10 Citationer (Scopus)

Abstract

In reduced preparations, hindlimb movements can be generated by a minimal network of neurons in the limb innervating spinal segments. The network of neurons that generates real movements is less well delineated. In an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans), we show that ventral horn interneurons in mid-thoracic spinal segments are functionally integrated in the hindlimb scratch network. First, mid-thoracic interneurons receive intense synaptic input during scratching and behave like neurons in the hindlimb enlargement. Second, some mid-thoracic interneurons activated during scratching project descending axons toward the hindlimb enlargement. Third, elimination of mid-thoracic segments leads to a weakening of scratch rhythmicity. We conclude that densely innervated interneurons in mid-thoracic segments contribute to hindlimb scratching and may be part of a distributed motor network that secures motor coherence.

Originalsprog	Engelsk
Tidsskrift	Journal of Neuroscience
Vol/bind	34
Udgave nummer	32
Sider (fra-til)	10756-10764
Antal sider	8
ISSN	0270-6474
DOI	https://doi.org/10.1523/JNEUROSCI.1079-14.2014
Status	Udgivet - 6 aug. 2014

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10.1523/JNEUROSCI.1079-14.2014

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AU - Guzulaitis, Robertas

AU - Hounsgaard, Jørn Dybkjær

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N2 - In reduced preparations, hindlimb movements can be generated by a minimal network of neurons in the limb innervating spinal segments. The network of neurons that generates real movements is less well delineated. In an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans), we show that ventral horn interneurons in mid-thoracic spinal segments are functionally integrated in the hindlimb scratch network. First, mid-thoracic interneurons receive intense synaptic input during scratching and behave like neurons in the hindlimb enlargement. Second, some mid-thoracic interneurons activated during scratching project descending axons toward the hindlimb enlargement. Third, elimination of mid-thoracic segments leads to a weakening of scratch rhythmicity. We conclude that densely innervated interneurons in mid-thoracic segments contribute to hindlimb scratching and may be part of a distributed motor network that secures motor coherence.

AB - In reduced preparations, hindlimb movements can be generated by a minimal network of neurons in the limb innervating spinal segments. The network of neurons that generates real movements is less well delineated. In an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans), we show that ventral horn interneurons in mid-thoracic spinal segments are functionally integrated in the hindlimb scratch network. First, mid-thoracic interneurons receive intense synaptic input during scratching and behave like neurons in the hindlimb enlargement. Second, some mid-thoracic interneurons activated during scratching project descending axons toward the hindlimb enlargement. Third, elimination of mid-thoracic segments leads to a weakening of scratch rhythmicity. We conclude that densely innervated interneurons in mid-thoracic segments contribute to hindlimb scratching and may be part of a distributed motor network that secures motor coherence.

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DO - 10.1523/JNEUROSCI.1079-14.2014

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Dense distributed processing in a hindlimb scratch motor network

Abstract

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