TY - JOUR
T1 - Demyelination versus remyelination in progressive multiple sclerosis
AU - Bramow, Stephan
AU - Frischer, Josa M
AU - Lassmann, Hans
AU - Koch-Henriksen, Nils
AU - Lucchinetti, Claudia F
AU - Sørensen, Per S
AU - Laursen, Henning
PY - 2010/10/1
Y1 - 2010/10/1
N2 - The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with 34 with secondary progressive disease. In patients with secondary progressive multiple sclerosis, we found larger brain plaques, more demyelination in total and higher brain loads of active demyelination compared with patients with primary progressive disease. In addition, the brain density of plaques with high-grade inflammation and active demyelination was highest in secondary progressive multiple sclerosis and remained ~18% higher than in primary progressive multiple sclerosis after adjustments for other plaque types and plaque number (P
AB - The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with 34 with secondary progressive disease. In patients with secondary progressive multiple sclerosis, we found larger brain plaques, more demyelination in total and higher brain loads of active demyelination compared with patients with primary progressive disease. In addition, the brain density of plaques with high-grade inflammation and active demyelination was highest in secondary progressive multiple sclerosis and remained ~18% higher than in primary progressive multiple sclerosis after adjustments for other plaque types and plaque number (P
U2 - 10.1093/brain/awq250
DO - 10.1093/brain/awq250
M3 - Journal article
SN - 0006-8950
VL - 133
SP - 2983
EP - 2998
JO - Brain
JF - Brain
IS - 10
ER -