@article{02bb3810194711deb43e000ea68e967b,
title = "Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques",
abstract = "To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.",
author = "Hernandez, {Ryan D} and Hubisz, {Melissa J} and Wheeler, {David A} and Smith, {David G} and Betsy Ferguson and Jeffrey Rogers and Lynne Nazareth and Amit Indap and Traci Bourquin and John McPherson and Donna Muzny and Richard Gibbs and Rasmus Nielsen and Bustamante, {Carlos D}",
note = "Keywords: Animals; China; DNA, Mitochondrial; Demography; Genetics, Medical; Humans; India; Linkage Disequilibrium; Macaca mulatta; Polymorphism, Single Nucleotide",
year = "2007",
doi = "10.1126/science.1140462",
language = "English",
volume = "316",
pages = "240--3",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5822",
}