Delayed Effect of Blood Flow-restricted Resistance Training on Rapid Force Capacity

Jakob Lindberg Nielsen; Ulrik Frandsen; Tatyana Prokhorova; Rune Dueholm Bech; Tobias Nygaard; Charlotte Suetta; Per Aagaard

doi:10.1249/MSS.0000000000001208

Delayed Effect of Blood Flow-restricted Resistance Training on Rapid Force Capacity

Jakob Lindberg Nielsen, Ulrik Frandsen, Tatyana Prokhorova, Rune Dueholm Bech, Tobias Nygaard, Charlotte Suetta, Per Aagaard

Institut for Klinisk Medicin

20 Citationer (Scopus)

Abstract

Purpose: The aim of the present study was to investigate the effect and time course of high-frequent low-load blood flow-restricted (BFR) resistance training on rapid force capacity (i.e., rate of torque development [RTD]). Materials and Methods: Ten male subjects (22.8 T 2.3 yr) performed four sets of knee extensor exercise (20% one-repetition maximum) to concentric failure during concurrent BFR of the thigh (100 mm Hg), and eight work-matched controls (21.9 T 3.0 yr) trained without BFR (CON). Twenty-three training sessions were performed within 19 d. Maximal slow and fast knee joint velocity muscle strength and rapid force capacity (e.g., RTD) and evoked twitch contractile parameters were assessed before (Pre) and 5 and 12 d after (Post5 and Post12) training. Muscle biopsies were obtained Pre, after 8 d (Mid8), and 3 and 10 d after (Post3 and Post10) training to examine changes in myofiber area and expression of myocellular proteins known to be modified by cellular stress (CaMKII, annexin A6, SNO-CYS). Results: RTD remained unchanged after BFR training at Post5, while increasing 15%-20% Post12 (P G 0.01). Evoked muscle twitch parameters showed a general decline Post5 (P G 0.01) while returning to baseline levels at Post12. All contractile parameters essentially remained unchanged in CON. Elevated CaMKII was observed with BFR training at Post3 (57%) and Post10 (71%) (P G 0.05), whereas SNO-CYS increased in CON at Mid8 (P G 0.05). Conclusion: This study is the first to show that low-load resistance exercise performed with BFR leads to marked increases in rapid force capacity (RTD). However, a general delayed adaptive response was observed for voluntary contractile parameters (including RTD) in parallel with a decline and subsequent recovery in evoked contractile properties, suggesting the delayed gain in rapid force capacity mainly have a peripheral origin.

Originalsprog	Engelsk
Tidsskrift	Medicine and Science in Sports and Exercise
Vol/bind	49
Udgave nummer	6
Sider (fra-til)	1157-1167
ISSN	0195-9131
DOI	https://doi.org/10.1249/MSS.0000000000001208
Status	Udgivet - 2017

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10.1249/MSS.0000000000001208

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@article{78dacc88ee1748998e4210e345579abc,

title = "Delayed Effect of Blood Flow-restricted Resistance Training on Rapid Force Capacity",

abstract = "Purpose: The aim of the present study was to investigate the effect and time course of high-frequent low-load blood flow-restricted (BFR) resistance training on rapid force capacity (i.e., rate of torque development [RTD]). Materials and Methods: Ten male subjects (22.8 T 2.3 yr) performed four sets of knee extensor exercise (20% one-repetition maximum) to concentric failure during concurrent BFR of the thigh (100 mm Hg), and eight work-matched controls (21.9 T 3.0 yr) trained without BFR (CON). Twenty-three training sessions were performed within 19 d. Maximal slow and fast knee joint velocity muscle strength and rapid force capacity (e.g., RTD) and evoked twitch contractile parameters were assessed before (Pre) and 5 and 12 d after (Post5 and Post12) training. Muscle biopsies were obtained Pre, after 8 d (Mid8), and 3 and 10 d after (Post3 and Post10) training to examine changes in myofiber area and expression of myocellular proteins known to be modified by cellular stress (CaMKII, annexin A6, SNO-CYS). Results: RTD remained unchanged after BFR training at Post5, while increasing 15%-20% Post12 (P G 0.01). Evoked muscle twitch parameters showed a general decline Post5 (P G 0.01) while returning to baseline levels at Post12. All contractile parameters essentially remained unchanged in CON. Elevated CaMKII was observed with BFR training at Post3 (57%) and Post10 (71%) (P G 0.05), whereas SNO-CYS increased in CON at Mid8 (P G 0.05). Conclusion: This study is the first to show that low-load resistance exercise performed with BFR leads to marked increases in rapid force capacity (RTD). However, a general delayed adaptive response was observed for voluntary contractile parameters (including RTD) in parallel with a decline and subsequent recovery in evoked contractile properties, suggesting the delayed gain in rapid force capacity mainly have a peripheral origin.",

keywords = "Humans, Male, Muscle Contraction/physiology, Muscle Proteins/metabolism, Muscle Strength/physiology, Muscle, Skeletal/blood supply, Pain Perception/physiology, Regional Blood Flow/physiology, Resistance Training/methods, Thigh/blood supply, Young Adult",

author = "Nielsen, {Jakob Lindberg} and Ulrik Frandsen and Tatyana Prokhorova and Bech, {Rune Dueholm} and Tobias Nygaard and Charlotte Suetta and Per Aagaard",

year = "2017",

doi = "10.1249/MSS.0000000000001208",

language = "English",

volume = "49",

pages = "1157--1167",

journal = "Medicine and Science in Sports and Exercise",

issn = "0195-9131",

publisher = "Lippincott Williams & Wilkins",

number = "6",

}

TY - JOUR

T1 - Delayed Effect of Blood Flow-restricted Resistance Training on Rapid Force Capacity

AU - Nielsen, Jakob Lindberg

AU - Frandsen, Ulrik

AU - Prokhorova, Tatyana

AU - Bech, Rune Dueholm

AU - Nygaard, Tobias

AU - Suetta, Charlotte

AU - Aagaard, Per

PY - 2017

Y1 - 2017

N2 - Purpose: The aim of the present study was to investigate the effect and time course of high-frequent low-load blood flow-restricted (BFR) resistance training on rapid force capacity (i.e., rate of torque development [RTD]). Materials and Methods: Ten male subjects (22.8 T 2.3 yr) performed four sets of knee extensor exercise (20% one-repetition maximum) to concentric failure during concurrent BFR of the thigh (100 mm Hg), and eight work-matched controls (21.9 T 3.0 yr) trained without BFR (CON). Twenty-three training sessions were performed within 19 d. Maximal slow and fast knee joint velocity muscle strength and rapid force capacity (e.g., RTD) and evoked twitch contractile parameters were assessed before (Pre) and 5 and 12 d after (Post5 and Post12) training. Muscle biopsies were obtained Pre, after 8 d (Mid8), and 3 and 10 d after (Post3 and Post10) training to examine changes in myofiber area and expression of myocellular proteins known to be modified by cellular stress (CaMKII, annexin A6, SNO-CYS). Results: RTD remained unchanged after BFR training at Post5, while increasing 15%-20% Post12 (P G 0.01). Evoked muscle twitch parameters showed a general decline Post5 (P G 0.01) while returning to baseline levels at Post12. All contractile parameters essentially remained unchanged in CON. Elevated CaMKII was observed with BFR training at Post3 (57%) and Post10 (71%) (P G 0.05), whereas SNO-CYS increased in CON at Mid8 (P G 0.05). Conclusion: This study is the first to show that low-load resistance exercise performed with BFR leads to marked increases in rapid force capacity (RTD). However, a general delayed adaptive response was observed for voluntary contractile parameters (including RTD) in parallel with a decline and subsequent recovery in evoked contractile properties, suggesting the delayed gain in rapid force capacity mainly have a peripheral origin.

AB - Purpose: The aim of the present study was to investigate the effect and time course of high-frequent low-load blood flow-restricted (BFR) resistance training on rapid force capacity (i.e., rate of torque development [RTD]). Materials and Methods: Ten male subjects (22.8 T 2.3 yr) performed four sets of knee extensor exercise (20% one-repetition maximum) to concentric failure during concurrent BFR of the thigh (100 mm Hg), and eight work-matched controls (21.9 T 3.0 yr) trained without BFR (CON). Twenty-three training sessions were performed within 19 d. Maximal slow and fast knee joint velocity muscle strength and rapid force capacity (e.g., RTD) and evoked twitch contractile parameters were assessed before (Pre) and 5 and 12 d after (Post5 and Post12) training. Muscle biopsies were obtained Pre, after 8 d (Mid8), and 3 and 10 d after (Post3 and Post10) training to examine changes in myofiber area and expression of myocellular proteins known to be modified by cellular stress (CaMKII, annexin A6, SNO-CYS). Results: RTD remained unchanged after BFR training at Post5, while increasing 15%-20% Post12 (P G 0.01). Evoked muscle twitch parameters showed a general decline Post5 (P G 0.01) while returning to baseline levels at Post12. All contractile parameters essentially remained unchanged in CON. Elevated CaMKII was observed with BFR training at Post3 (57%) and Post10 (71%) (P G 0.05), whereas SNO-CYS increased in CON at Mid8 (P G 0.05). Conclusion: This study is the first to show that low-load resistance exercise performed with BFR leads to marked increases in rapid force capacity (RTD). However, a general delayed adaptive response was observed for voluntary contractile parameters (including RTD) in parallel with a decline and subsequent recovery in evoked contractile properties, suggesting the delayed gain in rapid force capacity mainly have a peripheral origin.

KW - Humans

KW - Male

KW - Muscle Contraction/physiology

KW - Muscle Proteins/metabolism

KW - Muscle Strength/physiology

KW - Muscle, Skeletal/blood supply

KW - Pain Perception/physiology

KW - Regional Blood Flow/physiology

KW - Resistance Training/methods

KW - Thigh/blood supply

KW - Young Adult

U2 - 10.1249/MSS.0000000000001208

DO - 10.1249/MSS.0000000000001208

M3 - Journal article

C2 - 28121802

SN - 0195-9131

VL - 49

SP - 1157

EP - 1167

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

IS - 6

ER -

Delayed Effect of Blood Flow-restricted Resistance Training on Rapid Force Capacity

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