@article{f1ca1ef01bb511df8ed1000ea68e967b,
title = "Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells",
abstract = "IFN-α and skin-infiltrating activated T lymphocytes have important roles in the pathogenesis of psoriasis. T cells from psoriatic patients display an increased sensitivity to IFN-α, but the pathological mechanisms behind the hyperresponsiveness to IFN-α remained unknown. In this study, we show that psoriatic T cells display deficient expression of the suppressor of cytokine signaling (SOCS)3 in response to IFN-α and a low baseline expression of the SH2-domain-containing protein-tyrosine phosphatase (SHP)-1 when compared with skin T cells from nonpsoriatic donors. Moreover, IFN-α-stimulated psoriatic T cells show enhanced activation of JAKs (JAK1 and TYK2) and signal transducers and activators of transcription. Increased expression of SOCS3 proteins resulting from proteasomal blockade partially inhibits IFN-α response. Similarly, forced expression of SOCS3 and SHP-1 inhibits IFN-α signaling in psoriatic T cells. In conclusion, our data suggest that loss of regulatory control is involved in the aberrant hypersensitivity of psoriatic T cells to IFN-α.",
author = "Eriksen, {Karsten W} and Anders Woetmann and Lone Skov and Thorbj{\o}rn Krejsgaard and Bovin, {Lone F} and Hansen, {Mikkel L} and Kirsten Gr{\o}nb{\ae}k and Nils Billestrup and Nissen, {Mogens H} and Carsten Geisler and Wasik, {Mariusz A} and Niels Odum",
year = "2010",
month = jun,
doi = "10.1038/jid.2010.6",
language = "English",
volume = "130",
pages = "1590--7",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "nature publishing group",
number = "6",
}