Deficiency of 25-hydroxyvitamin D in male HIV-positive patients: a descriptive cross-sectional study

TY - JOUR

T1 - Deficiency of 25-hydroxyvitamin D in male HIV-positive patients: a descriptive cross-sectional study

AU - Bang, Ulrich Christian

AU - Shakar, Shakil A

AU - Hitz, Mette Friberg

AU - Jespersen, Mette Syberg

AU - Andersen, Ove

AU - Poulsen, Susanne Dam

AU - Jensen, Jens-Erik Beck

PY - 2010/4/1

Y1 - 2010/4/1

N2 - The aim of this descriptive cross-sectional study was to describe the prevalence of hypovitaminosis D in a cohort of HIV-seropositive males. Blood samples were collected in November and December 2004 and analyzed in the hospital laboratory. The concentration of 25-hydroxyvitamin D (25(OH)D) was defined as excellent when >75 nmol/l, normal when >50 nmol/l, insufficient when <50 nmol/l, deficient when <25 nmol/l and severely deficient when <12.5 nmol/l. Patient information was extracted from the medical records. A total of 115 males, median age 44 y (range 1963 y), were included in the study. The median 25(OH)D concentration was 43.0 nmol/l (range 8163 nmol/l) and the 25(OH)D level was excellent in 13%, normal in 27%, insufficient in 36%, deficient in 20%, and severely deficient in 4% of the cases. Vitamin D level was not associated with age, y with HIV infection, highly active antiretroviral therapy (HAART) or CD4 count. Compared to patients not in treatment, patients on HAART (n 71) had higher levels of total alkaline phosphatase (median 83.0 vs 75.5 U/l; p 0.031) and lower, though not significantly, total body mineral density (1.055 vs 1.107 g/cm2; p 0.077). This study confirms that the prevalence of hypovitaminosis is high among HIV-infected patients.

AB - The aim of this descriptive cross-sectional study was to describe the prevalence of hypovitaminosis D in a cohort of HIV-seropositive males. Blood samples were collected in November and December 2004 and analyzed in the hospital laboratory. The concentration of 25-hydroxyvitamin D (25(OH)D) was defined as excellent when >75 nmol/l, normal when >50 nmol/l, insufficient when <50 nmol/l, deficient when <25 nmol/l and severely deficient when <12.5 nmol/l. Patient information was extracted from the medical records. A total of 115 males, median age 44 y (range 1963 y), were included in the study. The median 25(OH)D concentration was 43.0 nmol/l (range 8163 nmol/l) and the 25(OH)D level was excellent in 13%, normal in 27%, insufficient in 36%, deficient in 20%, and severely deficient in 4% of the cases. Vitamin D level was not associated with age, y with HIV infection, highly active antiretroviral therapy (HAART) or CD4 count. Compared to patients not in treatment, patients on HAART (n 71) had higher levels of total alkaline phosphatase (median 83.0 vs 75.5 U/l; p 0.031) and lower, though not significantly, total body mineral density (1.055 vs 1.107 g/cm2; p 0.077). This study confirms that the prevalence of hypovitaminosis is high among HIV-infected patients.

U2 - 10.3109/00365540903463981

DO - 10.3109/00365540903463981

M3 - Journal article

SN - 0300-8878

VL - 42

SP - 306

EP - 310

JO - Scandinavian Journal of Infectious Diseases. Supplementum

JF - Scandinavian Journal of Infectious Diseases. Supplementum

IS - 4

ER -