Dam methylation: coordinating cellular processes

TY - JOUR

T1 - Dam methylation

T2 - coordinating cellular processes

AU - Løbner-Olesen, Anders

AU - Skovgaard, Ole

AU - Marinus, Martin G

PY - 2005/4

Y1 - 2005/4

N2 - GATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.

AB - GATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.

KW - Bacterial Physiological Phenomena

KW - DNA Methylation

KW - DNA, Bacterial/metabolism

KW - Escherichia coli Proteins

KW - Gene Expression Regulation, Bacterial

KW - Site-Specific DNA-Methyltransferase (Adenine-Specific)/genetics

U2 - 10.1016/j.mib.2005.02.009

DO - 10.1016/j.mib.2005.02.009

M3 - Review

C2 - 15802246

SN - 1369-5274

VL - 8

SP - 154

EP - 160

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

IS - 2

ER -