TY - JOUR
T1 - Dairy Consumption and Body Mass Index Among Adults
T2 - Mendelian Randomization Analysis of 184802 Individuals from 25 Studies
AU - Sørensen, Thorkild I.A.
AU - Linneberg, Allan René
AU - Mendelian Randomization of Dairy Consumption Working Group
N1 - © 2017 American Association for Clinical Chemistry.
PY - 2018/1
Y1 - 2018/1
N2 - BACKGROUND: Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined. METHODS: We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (LCT- 13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between (a) dairy intake and BMI, (b) rs4988235 and dairy intake, and (c) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies. RESULTS: Higher dairy intake was associated with higher BMI (β = 0.03 kg/m2 per serving/day; 95% CI, 0.00- 0.06; P=0.04), whereas the LCT genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14-0.25) serving/day higher dairy intake (P=3.15 x 1012) and 0.12 (95% CI, 0.06-0.17) kg/m2 higher BMI (P = 2.11 x 105,). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m2 per serving/day; 95% CI, 0.27- 0.92; P = 3.0 x 104). CONCLUSIONS: The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.
AB - BACKGROUND: Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined. METHODS: We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (LCT- 13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between (a) dairy intake and BMI, (b) rs4988235 and dairy intake, and (c) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies. RESULTS: Higher dairy intake was associated with higher BMI (β = 0.03 kg/m2 per serving/day; 95% CI, 0.00- 0.06; P=0.04), whereas the LCT genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14-0.25) serving/day higher dairy intake (P=3.15 x 1012) and 0.12 (95% CI, 0.06-0.17) kg/m2 higher BMI (P = 2.11 x 105,). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m2 per serving/day; 95% CI, 0.27- 0.92; P = 3.0 x 104). CONCLUSIONS: The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.
U2 - 10.1373/clinchem.2017.280701
DO - 10.1373/clinchem.2017.280701
M3 - Journal article
C2 - 29187356
SN - 0009-9147
VL - 64
SP - 183
EP - 191
JO - Clinical Chemistry
JF - Clinical Chemistry
IS - 1
ER -