Cytokines (immunoinflammatory hormones) and their natural regulation in inflammatory bowel disease (Crohn's disease and ulcerative colitis): a review

TY - JOUR

T1 - Cytokines (immunoinflammatory hormones) and their natural regulation in inflammatory bowel disease (Crohn's disease and ulcerative colitis)

T2 - a review

AU - Brynskov, J

AU - Nielsen, O H

AU - Ahnfelt-Rønne, I

AU - Bendtzen, K

PY - 1994/9/1

Y1 - 1994/9/1

N2 - Cytokines, particularly the proinflammatory cytokines, whose role and natural regulation in inflammatory bowel disease are reviewed here, are produced by many cell types, including immune cells. Cytokines function as important hormones of the immune system, and many act both regionally and systemically via specific receptors. The demonstration of increased circulating and mucosal levels of proinflammatory (and other) cytokines (and receptors) in active inflammatory bowel disease does not by itself constitute any proof as to the primary involvement of these mediators. However, they may contribute significantly to disease manifestations, and specific therapeutic intervention at the cytokine or cytokine receptor level may show up to be clinically most relevant. This is underscored by the increasing evidence that proven therapies of inflammatory bowel disease to a great extent seem to function through cytokine modulation.

AB - Cytokines, particularly the proinflammatory cytokines, whose role and natural regulation in inflammatory bowel disease are reviewed here, are produced by many cell types, including immune cells. Cytokines function as important hormones of the immune system, and many act both regionally and systemically via specific receptors. The demonstration of increased circulating and mucosal levels of proinflammatory (and other) cytokines (and receptors) in active inflammatory bowel disease does not by itself constitute any proof as to the primary involvement of these mediators. However, they may contribute significantly to disease manifestations, and specific therapeutic intervention at the cytokine or cytokine receptor level may show up to be clinically most relevant. This is underscored by the increasing evidence that proven therapies of inflammatory bowel disease to a great extent seem to function through cytokine modulation.

KW - Animals

KW - Anti-Inflammatory Agents/therapeutic use

KW - Colitis, Ulcerative/drug therapy

KW - Crohn Disease/drug therapy

KW - Cytokines/antagonists & inhibitors

KW - Humans

KW - Immunosuppressive Agents/therapeutic use

KW - Interleukins/antagonists & inhibitors

KW - Tumor Necrosis Factor-alpha/antagonists & inhibitors

U2 - 10.1159/000171464

DO - 10.1159/000171464

M3 - Review

C2 - 7882549

SN - 0257-2753

VL - 12

SP - 290

EP - 304

JO - Digestive Diseases

JF - Digestive Diseases

IS - 5

ER -