Cyclodextrin-based artificial enzymes: synthesis and function

TY - CHAP

T1 - Cyclodextrin-based artificial enzymes

T2 - synthesis and function

AU - Pedersen, Christian Marcus

AU - Bols, Mikael

PY - 2013/10/25

Y1 - 2013/10/25

N2 - The most common and hence commercially available cyclodextrins consist of 6, 7, or 8 α-1,4-linked D-glucosyl units, which form a conical bucket-like structure. The remaining hydroxyl groups, that is, 2-OH, 3-OH, and 6-OH, are all placed on the outside of the bucket, making it polar and hydrophilic. The cavity, however, is apolar and can therefore bind small hydrophobic compounds. The ability to complex apolar molecules in their cavity, thereby making them soluble in aqueous solvents, has led to many industrial uses, especially as a food ingredient and as a flavor/aroma stabilizer. In particular, the complexation of compounds in aqueous solutions has gained interest, and cyclodextrin-based artificial enzymes (chemzymes) have been developed during the last three decades.

AB - The most common and hence commercially available cyclodextrins consist of 6, 7, or 8 α-1,4-linked D-glucosyl units, which form a conical bucket-like structure. The remaining hydroxyl groups, that is, 2-OH, 3-OH, and 6-OH, are all placed on the outside of the bucket, making it polar and hydrophilic. The cavity, however, is apolar and can therefore bind small hydrophobic compounds. The ability to complex apolar molecules in their cavity, thereby making them soluble in aqueous solvents, has led to many industrial uses, especially as a food ingredient and as a flavor/aroma stabilizer. In particular, the complexation of compounds in aqueous solutions has gained interest, and cyclodextrin-based artificial enzymes (chemzymes) have been developed during the last three decades.

U2 - 10.1002/9781118736449.ch11

DO - 10.1002/9781118736449.ch11

M3 - Book chapter

SN - 9781118150924

SP - 305

EP - 332

BT - Organic synthesis and molecular engineering

A2 - Brøndsted Nielsen, Mogens

PB - Wiley

ER -