Cubosomes and hexosomes as versatile platforms for drug delivery

Intan Diana Binti Mat Azmi; Seyed M Moghimi; Anan Yaghmur

doi:10.4155/tde.15.81

Cubosomes and hexosomes as versatile platforms for drug delivery

Intan Diana Binti Mat Azmi, Seyed M Moghimi, Anan Yaghmur

81 Citationer (Scopus)

Abstract

Nonlamellar liquid crystalline phases are attractive platforms for drug solubilization and targeted delivery. The attractiveness of this formulation principle is linked to the nanostructural versatility, compatiblity, digestiblity and bioadhesive properties of their lipid constituents, and the capability of solubilizing and sustaining the release of amphiphilic, hydrophobic and hydrophilic drugs. Nonlamellar liquid crystalline phases offer two distinct promising strategies in the development of drug delivery systems. These comprise formation of ISAsomes (internally self-assembled ‘somes’ or particles) such as cubosomes and hexosomes, and in situ formation of parenteral dosage forms with tunable nanostructures at the site of administration. This review outlines the unique features of cubosomes and hexosomes and their potential utilization as promising platforms for drug delivery.

Originalsprog	Engelsk
Tidsskrift	Therapeutic Delivery
Vol/bind	6
Udgave nummer	12
Sider (fra-til)	1347-64
Antal sider	18
ISSN	2041-5990
DOI	https://doi.org/10.4155/tde.15.81
Status	Udgivet - dec. 2015

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10.4155/tde.15.81

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title = "Cubosomes and hexosomes as versatile platforms for drug delivery",

abstract = "Nonlamellar liquid crystalline phases are attractive platforms for drug solubilization and targeted delivery. The attractiveness of this formulation principle is linked to the nanostructural versatility, compatiblity, digestiblity and bioadhesive properties of their lipid constituents, and the capability of solubilizing and sustaining the release of amphiphilic, hydrophobic and hydrophilic drugs. Nonlamellar liquid crystalline phases offer two distinct promising strategies in the development of drug delivery systems. These comprise formation of ISAsomes (internally self-assembled 'somes' or particles) such as cubosomes and hexosomes, and in situ formation of parenteral dosage forms with tunable nanostructures at the site of administration. This review outlines the unique features of cubosomes and hexosomes and their potential utilization as promising platforms for drug delivery.",

author = "{Mat Azmi}, {Intan Diana Binti} and Moghimi, {Seyed M} and Anan Yaghmur",

year = "2015",

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AU - Mat Azmi, Intan Diana Binti

AU - Moghimi, Seyed M

AU - Yaghmur, Anan

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Y1 - 2015/12

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AB - Nonlamellar liquid crystalline phases are attractive platforms for drug solubilization and targeted delivery. The attractiveness of this formulation principle is linked to the nanostructural versatility, compatiblity, digestiblity and bioadhesive properties of their lipid constituents, and the capability of solubilizing and sustaining the release of amphiphilic, hydrophobic and hydrophilic drugs. Nonlamellar liquid crystalline phases offer two distinct promising strategies in the development of drug delivery systems. These comprise formation of ISAsomes (internally self-assembled 'somes' or particles) such as cubosomes and hexosomes, and in situ formation of parenteral dosage forms with tunable nanostructures at the site of administration. This review outlines the unique features of cubosomes and hexosomes and their potential utilization as promising platforms for drug delivery.

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DO - 10.4155/tde.15.81

M3 - Journal article

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VL - 6

SP - 1347

EP - 1364

JO - Therapeutic Delivery

JF - Therapeutic Delivery

IS - 12

ER -

Cubosomes and hexosomes as versatile platforms for drug delivery

Abstract

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