Cover picture: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds

TY - JOUR

T1 - Cover picture: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds

AU - Thanh Tung, Truong

AU - Christensen, Søren Brøgger

AU - Nielsen, John

PY - 2017/10/25

Y1 - 2017/10/25

N2 - Direct C−H difluoromethylation of electron-deficient positions in nitrogen-containing heterocycles is attained by difluoromethyl radicals generated in-situ from difluoroacetic acid under silver-catalyzed oxidative decarboxylation. Control of the reaction temperature permits either mono- or disubstitution. More information can be found in the Communication by J. Nielsen et al. (DOI: 10.1002/chem.201704261).

AB - Direct C−H difluoromethylation of electron-deficient positions in nitrogen-containing heterocycles is attained by difluoromethyl radicals generated in-situ from difluoroacetic acid under silver-catalyzed oxidative decarboxylation. Control of the reaction temperature permits either mono- or disubstitution. More information can be found in the Communication by J. Nielsen et al. (DOI: 10.1002/chem.201704261).

M3 - Journal article

SN - 0947-6539

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

ER -