Copeptin levels and invasive hemodynamics in patients with advanced heart failure

Louise Balling; Jens Peter Goetze; Mette Holme Jung; Kasper Rossing; Soeren Boesgaard; Finn Gustafsson

doi:10.2217/bmm-2017-0439

Copeptin levels and invasive hemodynamics in patients with advanced heart failure

Louise Balling, Jens Peter Goetze, Mette Holme Jung, Kasper Rossing, Soeren Boesgaard, Finn Gustafsson

2 Citationer (Scopus)

Abstract

AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.

METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).

CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.

Originalsprog	Engelsk
Tidsskrift	Biomarkers in Medicine
Vol/bind	12
Udgave nummer	8
Sider (fra-til)	861-870
Antal sider	10
ISSN	1752-0363
DOI	https://doi.org/10.2217/bmm-2017-0439
Status	Udgivet - aug. 2018

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10.2217/bmm-2017-0439

Citationsformater

@article{d41d8b241a5b4b0599e9b8cc791c3da7,

title = "Copeptin levels and invasive hemodynamics in patients with advanced heart failure",

abstract = "AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.",

author = "Louise Balling and Goetze, {Jens Peter} and Jung, {Mette Holme} and Kasper Rossing and Soeren Boesgaard and Finn Gustafsson",

year = "2018",

month = aug,

doi = "10.2217/bmm-2017-0439",

language = "English",

volume = "12",

pages = "861--870",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

number = "8",

}

TY - JOUR

T1 - Copeptin levels and invasive hemodynamics in patients with advanced heart failure

AU - Balling, Louise

AU - Goetze, Jens Peter

AU - Jung, Mette Holme

AU - Rossing, Kasper

AU - Boesgaard, Soeren

AU - Gustafsson, Finn

PY - 2018/8

Y1 - 2018/8

N2 - AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.

AB - AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.

U2 - 10.2217/bmm-2017-0439

DO - 10.2217/bmm-2017-0439

M3 - Journal article

C2 - 30058349

SN - 1752-0363

VL - 12

SP - 861

EP - 870

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 8

ER -

Copeptin levels and invasive hemodynamics in patients with advanced heart failure

Abstract

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