Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA

TY - JOUR

T1 - Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA

AU - Weng, Ruifen

AU - Cohen, Stephen M

N1 - © 2015. Published by The Company of Biologists Ltd.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain.

AB - Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain.

U2 - 10.1242/dev.127209

DO - 10.1242/dev.127209

M3 - Journal article

C2 - 26395494

SN - 0950-1991

VL - 142

SP - 3713

EP - 3720

JO - Development

JF - Development

IS - 21

ER -