Contact allergy to common ingredients in hair dyes

Heidi Søsted; Thomas Rustemeyer; Margarida Gonçalo; Magnus Bruze; An Goossens; Ana M Giménez-Arnau; Christophe J Le Coz; Ian R White; Thomas L Diepgen; Klaus Andersen; Tove Agner; Howard Maibach; Torkil Menné; Jeanne D Johansen

doi:10.1111/cod.12077

Contact allergy to common ingredients in hair dyes

Heidi Søsted, Thomas Rustemeyer, Margarida Gonçalo, Magnus Bruze, An Goossens, Ana M Giménez-Arnau, Christophe J Le Coz, Ian R White, Thomas L Diepgen, Klaus Andersen, Tove Agner, Howard Maibach, Torkil Menné, Jeanne D Johansen

58 Citationer (Scopus)

Abstract

Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of ∼ 500 patients each. Results A positive reaction to PPD was found in 4.5% of patients, and 2.8% reacted to toluene-2,5-diamine (PTD), 1.8% to p-aminophenol, 1% to m-aminophenol, and 0.1% to resorcinol; all together, 5.3% (n = 156). Dying hair was the most frequently reported cause of the allergy (55.4%); so-called 'temporary henna' tattoos were the cause in 8.5% of the cases. p-Methylaminophenol gave a reaction in 20 patients (2.2%), 3 of them with clinical relevance, and no co-reaction with the above five well-known hair dyes. Conclusions Hair dyes are the prime cause of PPD allergy. PPD identifies the majority of positive reactions to PTD, p-aminophenol and m-aminophenol, but not all, which justifies additional testing with hair dye ingredients from the used product.

Originalsprog	Engelsk
Tidsskrift	Contact Dermatitis
Vol/bind	69
Udgave nummer	1
Sider (fra-til)	32-39
Antal sider	8
ISSN	0105-1873
DOI	https://doi.org/10.1111/cod.12077
Status	Udgivet - jul. 2013

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10.1111/cod.12077

Citationsformater

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title = "Contact allergy to common ingredients in hair dyes",

abstract = "Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of ∼ 500 patients each. Results A positive reaction to PPD was found in 4.5% of patients, and 2.8% reacted to toluene-2,5-diamine (PTD), 1.8% to p-aminophenol, 1% to m-aminophenol, and 0.1% to resorcinol; all together, 5.3% (n = 156). Dying hair was the most frequently reported cause of the allergy (55.4%); so-called 'temporary henna' tattoos were the cause in 8.5% of the cases. p-Methylaminophenol gave a reaction in 20 patients (2.2%), 3 of them with clinical relevance, and no co-reaction with the above five well-known hair dyes. Conclusions Hair dyes are the prime cause of PPD allergy. PPD identifies the majority of positive reactions to PTD, p-aminophenol and m-aminophenol, but not all, which justifies additional testing with hair dye ingredients from the used product.",

author = "Heidi S{\o}sted and Thomas Rustemeyer and Margarida Gon{\c c}alo and Magnus Bruze and An Goossens and Gim{\'e}nez-Arnau, {Ana M} and {Le Coz}, {Christophe J} and White, {Ian R} and Diepgen, {Thomas L} and Klaus Andersen and Tove Agner and Howard Maibach and Torkil Menn{\'e} and Johansen, {Jeanne D}",

year = "2013",

month = jul,

doi = "10.1111/cod.12077",

language = "English",

volume = "69",

pages = "32--39",

journal = "Contact Dermatitis",

issn = "0105-1873",

publisher = "Wiley-Blackwell",

number = "1",

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TY - JOUR

T1 - Contact allergy to common ingredients in hair dyes

AU - Søsted, Heidi

AU - Rustemeyer, Thomas

AU - Gonçalo, Margarida

AU - Bruze, Magnus

AU - Goossens, An

AU - Giménez-Arnau, Ana M

AU - Le Coz, Christophe J

AU - White, Ian R

AU - Diepgen, Thomas L

AU - Andersen, Klaus

AU - Agner, Tove

AU - Maibach, Howard

AU - Menné, Torkil

AU - Johansen, Jeanne D

PY - 2013/7

Y1 - 2013/7

N2 - Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of ∼ 500 patients each. Results A positive reaction to PPD was found in 4.5% of patients, and 2.8% reacted to toluene-2,5-diamine (PTD), 1.8% to p-aminophenol, 1% to m-aminophenol, and 0.1% to resorcinol; all together, 5.3% (n = 156). Dying hair was the most frequently reported cause of the allergy (55.4%); so-called 'temporary henna' tattoos were the cause in 8.5% of the cases. p-Methylaminophenol gave a reaction in 20 patients (2.2%), 3 of them with clinical relevance, and no co-reaction with the above five well-known hair dyes. Conclusions Hair dyes are the prime cause of PPD allergy. PPD identifies the majority of positive reactions to PTD, p-aminophenol and m-aminophenol, but not all, which justifies additional testing with hair dye ingredients from the used product.

AB - Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of ∼ 500 patients each. Results A positive reaction to PPD was found in 4.5% of patients, and 2.8% reacted to toluene-2,5-diamine (PTD), 1.8% to p-aminophenol, 1% to m-aminophenol, and 0.1% to resorcinol; all together, 5.3% (n = 156). Dying hair was the most frequently reported cause of the allergy (55.4%); so-called 'temporary henna' tattoos were the cause in 8.5% of the cases. p-Methylaminophenol gave a reaction in 20 patients (2.2%), 3 of them with clinical relevance, and no co-reaction with the above five well-known hair dyes. Conclusions Hair dyes are the prime cause of PPD allergy. PPD identifies the majority of positive reactions to PTD, p-aminophenol and m-aminophenol, but not all, which justifies additional testing with hair dye ingredients from the used product.

U2 - 10.1111/cod.12077

DO - 10.1111/cod.12077

M3 - Journal article

C2 - 23782356

SN - 0105-1873

VL - 69

SP - 32

EP - 39

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 1

ER -

Contact allergy to common ingredients in hair dyes

Abstract

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