Constrained vertebrate evolution by pleiotropic genes

Haiyang Hu; Masahiro Uesaka; Song Guo; Kotaro Shimai; Tsai-Ming Lu; Fang Li; Satoko Fujimoto; Masato Ishikawa; Shiping Liu; Yohei Sasagawa; Guojie Zhang; Shigeru Kuratani; Jr-Kai Yu; Takehiro G. Kusakabe; Philipp Khaitovich; Naoki Irie

doi:10.1038/s41559-017-0318-0

Constrained vertebrate evolution by pleiotropic genes

Haiyang Hu, Masahiro Uesaka, Song Guo, Kotaro Shimai, Tsai-Ming Lu, Fang Li, Satoko Fujimoto, Masato Ishikawa, Shiping Liu, Yohei Sasagawa, Guojie Zhang, Shigeru Kuratani, Jr-Kai Yu, Takehiro G. Kusakabe, Philipp Khaitovich, Naoki Irie^*

^*Corresponding author af dette arbejde

Ecology and Evolution

36 Citationer (Scopus)

Abstract

Despite morphological diversification of chordates over 550 million years of evolution, their shared basic anatomical pattern (or 'bodyplan') remains conserved by unknown mechanisms. The developmental hourglass model attributes this to phylum-wide conserved, constrained organogenesis stages that pattern the bodyplan (the phylotype hypothesis); however, there has been no quantitative testing of this idea with a phylum-wide comparison of species. Here, based on data from early-to-late embryonic transcriptomes collected from eight chordates, we suggest that the phylotype hypothesis would be better applied to vertebrates than chordates. Furthermore, we found that vertebrates' conserved mid-embryonic developmental programmes are intensively recruited to other developmental processes, and the degree of the recruitment positively correlates with their evolutionary conservation and essentiality for normal development. Thus, we propose that the intensively recruited genetic system during vertebrates' organogenesis period imposed constraints on its diversification through pleiotropic constraints, which ultimately led to the common anatomical pattern observed in vertebrates.

Originalsprog	Engelsk
Tidsskrift	Nature Ecology and Evolution
Vol/bind	1
Udgave nummer	11
Sider (fra-til)	1722-1730
Antal sider	9
ISSN	2397-334X
DOI	https://doi.org/10.1038/s41559-017-0318-0
Status	Udgivet - nov. 2017

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AU - Li, Fang

AU - Fujimoto, Satoko

AU - Ishikawa, Masato

AU - Liu, Shiping

AU - Sasagawa, Yohei

AU - Zhang, Guojie

AU - Kuratani, Shigeru

AU - Yu, Jr-Kai

AU - Kusakabe, Takehiro G.

AU - Khaitovich, Philipp

AU - Irie, Naoki

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Constrained vertebrate evolution by pleiotropic genes

Abstract

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