Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review

TY - JOUR

T1 - Considering treatment of male genital schistosomiasis as a tool for future HIV prevention

T2 - a systematic review

AU - Stecher, Chalotte Willemann

AU - Kallestrup, Per

AU - Kjetland, Eyrun Floerecke

AU - Vennervald, Birgitte J

AU - Petersen, Jørgen Eskild

PY - 2015/8/23

Y1 - 2015/8/23

N2 - OBJECTIVES: Male genital schistosomiasis (MGS) is a neglected manifestation of Schistosoma haematobium infection with ignored implications on reproductive health and a differential diagnosis to sexually transmitted infections in endemic regions. MGS may have associations with HIV transmission and acquisition, and treatment could be a neglected chance of HIV prevention. This review summarizes current knowledge on epidemiology, clinical manifestations, diagnosis and treatment of MGS as a hypothesized risk factor for HIV transmission. Future research areas of global interest are suggested.METHODS: PubMed published literature was reviewed based on the MOOSE guidelines. All publications on MGS were included regardless of publication year and study design. Furthermore, all publications were searched for information on possible HIV association.RESULTS: The 40 identified publications related to MGS were dominated by case reports and observational studies. No randomized clinical trials have been conducted to date, and very scant information related to possible associations with HIV transmission was presented.CONCLUSIONS: Clinical, randomized studies and epidemiological studies covering the possible association between MGS and HIV are urgently needed. Furthermore, field diagnostic tools should be developed and future mass treatment programs should include adults to reduce morbidity and prevent HIV acquisition.SYSTEMATIC REVIEW REGISTRATION NUMBER: CRD42015016252.

AB - OBJECTIVES: Male genital schistosomiasis (MGS) is a neglected manifestation of Schistosoma haematobium infection with ignored implications on reproductive health and a differential diagnosis to sexually transmitted infections in endemic regions. MGS may have associations with HIV transmission and acquisition, and treatment could be a neglected chance of HIV prevention. This review summarizes current knowledge on epidemiology, clinical manifestations, diagnosis and treatment of MGS as a hypothesized risk factor for HIV transmission. Future research areas of global interest are suggested.METHODS: PubMed published literature was reviewed based on the MOOSE guidelines. All publications on MGS were included regardless of publication year and study design. Furthermore, all publications were searched for information on possible HIV association.RESULTS: The 40 identified publications related to MGS were dominated by case reports and observational studies. No randomized clinical trials have been conducted to date, and very scant information related to possible associations with HIV transmission was presented.CONCLUSIONS: Clinical, randomized studies and epidemiological studies covering the possible association between MGS and HIV are urgently needed. Furthermore, field diagnostic tools should be developed and future mass treatment programs should include adults to reduce morbidity and prevent HIV acquisition.SYSTEMATIC REVIEW REGISTRATION NUMBER: CRD42015016252.

U2 - 10.1007/s00038-015-0714-7

DO - 10.1007/s00038-015-0714-7

M3 - Journal article

C2 - 26298443

SN - 1661-8556

VL - 60

SP - 839

EP - 848

JO - International Journal of Public Health (Print Edition)

JF - International Journal of Public Health (Print Edition)

IS - 7

ER -