Connexins and the kidney

Fiona Hanner; Charlotte Mehlin Sørensen; Niels-Henrik Holstein-Rathlou; János Peti-Peterdi

doi:10.1152/ajpregu.00808.2009

Connexins and the kidney

Fiona Hanner, Charlotte Mehlin Sørensen, Niels-Henrik Holstein-Rathlou, János Peti-Peterdi

Nyre- og Karforskning

106 Citationer (Scopus)

Abstract

Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap junction plaques only in the proximal tubules. In the distal nephron, Cx30, Cx30.3, and Cx37 are expressed, but it is not known whether they form gap junctions connecting neighboring cells or whether they primarily act as hemichannels. As in other systems, the major function of Cxs in the kidney appears to be intercellular communication, although they may also form hemichannels that allow cellular secretion of large signaling molecules. Renal Cxs facilitate vascular conduction, juxtaglomerular apparatus calcium signaling, and tubular purinergic signaling. Accordingly, current evidence points to roles for these Cxs in several important regulatory mechanisms in the kidney, including the renin angiotensin system, tubuloglomerular feedback, and salt and water reabsorption. At the systemic level, renal Cxs may help regulate blood pressure and may be involved in hypertension and diabetes.

Originalsprog	Engelsk
Tidsskrift	American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Vol/bind	298
Udgave nummer	5
Sider (fra-til)	R1143-55
Antal sider	13
ISSN	0363-6119
DOI	https://doi.org/10.1152/ajpregu.00808.2009
Status	Udgivet - maj 2010

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10.1152/ajpregu.00808.2009

Citationsformater

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title = "Connexins and the kidney",

abstract = "Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap junction plaques only in the proximal tubules. In the distal nephron, Cx30, Cx30.3, and Cx37 are expressed, but it is not known whether they form gap junctions connecting neighboring cells or whether they primarily act as hemichannels. As in other systems, the major function of Cxs in the kidney appears to be intercellular communication, although they may also form hemichannels that allow cellular secretion of large signaling molecules. Renal Cxs facilitate vascular conduction, juxtaglomerular apparatus calcium signaling, and tubular purinergic signaling. Accordingly, current evidence points to roles for these Cxs in several important regulatory mechanisms in the kidney, including the renin angiotensin system, tubuloglomerular feedback, and salt and water reabsorption. At the systemic level, renal Cxs may help regulate blood pressure and may be involved in hypertension and diabetes.",

keywords = "Animals, Connexins, Gap Junctions, Humans, Kidney, Renin-Angiotensin System, Water-Electrolyte Balance",

author = "Fiona Hanner and S{\o}rensen, {Charlotte Mehlin} and Niels-Henrik Holstein-Rathlou and J{\'a}nos Peti-Peterdi",

year = "2010",

month = may,

doi = "10.1152/ajpregu.00808.2009",

language = "English",

volume = "298",

pages = "R1143--55",

journal = "American Journal of Physiology: Regulatory, Integrative and Comparative Physiology",

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TY - JOUR

T1 - Connexins and the kidney

AU - Hanner, Fiona

AU - Sørensen, Charlotte Mehlin

AU - Holstein-Rathlou, Niels-Henrik

AU - Peti-Peterdi, János

PY - 2010/5

Y1 - 2010/5

N2 - Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap junction plaques only in the proximal tubules. In the distal nephron, Cx30, Cx30.3, and Cx37 are expressed, but it is not known whether they form gap junctions connecting neighboring cells or whether they primarily act as hemichannels. As in other systems, the major function of Cxs in the kidney appears to be intercellular communication, although they may also form hemichannels that allow cellular secretion of large signaling molecules. Renal Cxs facilitate vascular conduction, juxtaglomerular apparatus calcium signaling, and tubular purinergic signaling. Accordingly, current evidence points to roles for these Cxs in several important regulatory mechanisms in the kidney, including the renin angiotensin system, tubuloglomerular feedback, and salt and water reabsorption. At the systemic level, renal Cxs may help regulate blood pressure and may be involved in hypertension and diabetes.

AB - Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap junction plaques only in the proximal tubules. In the distal nephron, Cx30, Cx30.3, and Cx37 are expressed, but it is not known whether they form gap junctions connecting neighboring cells or whether they primarily act as hemichannels. As in other systems, the major function of Cxs in the kidney appears to be intercellular communication, although they may also form hemichannels that allow cellular secretion of large signaling molecules. Renal Cxs facilitate vascular conduction, juxtaglomerular apparatus calcium signaling, and tubular purinergic signaling. Accordingly, current evidence points to roles for these Cxs in several important regulatory mechanisms in the kidney, including the renin angiotensin system, tubuloglomerular feedback, and salt and water reabsorption. At the systemic level, renal Cxs may help regulate blood pressure and may be involved in hypertension and diabetes.

KW - Animals

KW - Connexins

KW - Gap Junctions

KW - Humans

KW - Kidney

KW - Renin-Angiotensin System

KW - Water-Electrolyte Balance

U2 - 10.1152/ajpregu.00808.2009

DO - 10.1152/ajpregu.00808.2009

M3 - Journal article

C2 - 20164205

SN - 0363-6119

VL - 298

SP - R1143-55

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

IS - 5

ER -

Connexins and the kidney

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