Concordance for prognostic models with competing risks

TY - JOUR

T1 - Concordance for prognostic models with competing risks

AU - Wolbers, Marcel

AU - Blanche, Paul

AU - Koller, Michael T

AU - Witteman, Jacqueline C M

AU - Gerds, Thomas A

N1 - © The Author 2014. Published by Oxford University Press.

PY - 2014/7

Y1 - 2014/7

N2 - The concordance probability is a widely used measure to assess discrimination of prognostic models with binary and survival endpoints. We formally define the concordance probability for a prognostic model of the absolute risk of an event of interest in the presence of competing risks and relate it to recently proposed time-dependent area under the receiver operating characteristic curve measures. For right-censored data, we investigate inverse probability of censoring weighted (IPCW) estimates of a truncated concordance index based on a working model for the censoring distribution. We demonstrate consistency and asymptotic normality of the IPCW estimate if the working model is correctly specified and derive an explicit formula for the asymptotic variance under independent censoring. The small sample properties of the estimator are assessed in a simulation study also against misspecification of the working model. We further illustrate the methods by computing the concordance probability for a prognostic model of coronary heart disease (CHD) events in the presence of the competing risk of non-CHD death.

AB - The concordance probability is a widely used measure to assess discrimination of prognostic models with binary and survival endpoints. We formally define the concordance probability for a prognostic model of the absolute risk of an event of interest in the presence of competing risks and relate it to recently proposed time-dependent area under the receiver operating characteristic curve measures. For right-censored data, we investigate inverse probability of censoring weighted (IPCW) estimates of a truncated concordance index based on a working model for the censoring distribution. We demonstrate consistency and asymptotic normality of the IPCW estimate if the working model is correctly specified and derive an explicit formula for the asymptotic variance under independent censoring. The small sample properties of the estimator are assessed in a simulation study also against misspecification of the working model. We further illustrate the methods by computing the concordance probability for a prognostic model of coronary heart disease (CHD) events in the presence of the competing risk of non-CHD death.

U2 - 10.1093/biostatistics/kxt059

DO - 10.1093/biostatistics/kxt059

M3 - Journal article

C2 - 24493091

SN - 1465-4644

VL - 15

SP - 526

EP - 539

JO - Biostatistics

JF - Biostatistics

IS - 3

ER -